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. 2018 May 15;9(37):24766–24777. doi: 10.18632/oncotarget.25346

Figure 4. Detailed analysis of arboreal protrusions formed by cells invading the surrounding hydrogel matrix.

Figure 4

(A) Comparison between cell protrusions of spheroids from of U87MG cells alone and from U87MG cells with transduced MSC at day 7. Protrusions in the hydrogel matrix are mostly filled by red fluorescent U87MG cells. Scale bar: 400 µm. (B) 3D cell invasion experiment with U87MG cells co-cultivated with GFP+MSC demonstrating that MSC are visible in the tumor spheroids at day 0 and 3. At day 7, developed arboreal protrusions are predominantly filled by red fluorescent tumor cells. Spheroids comprised only by GFP+MSC or by FP635+U87MG cells are shown for comparison.