Figure 3.

Concentration-dependent inhibition of TNF superfamily PPIs by the compounds of the present study (6–19; Table 1) in a cell-free ELISA-type assay. Data are (counterclockwise) for human CD40–CD154 (CD40L) (A); OX40–OX40L (B); BAFFR–BAFF (C); and TNF-R1–TNFα (D) and were fitted with standard binding curves. Data are average ± SD (normalized to percent binding) for n = 3 independent experiments with duplicates for each condition.