MICROBIOLOGY. For the article “Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors” by Sukhanya Jayachandra, Kenneth G. Low, Ai-En Thlick, Jin Yu, Paul D. Ling, Yuan Chang, and Patrick S. Moore, which appeared in number 20, September 28, 1999, of Proc. Natl. Acad. Sci. USA (96, 11566–11571), the undersigned authors wish to report the following. “Despite repeated attempts, we have been unable to repeat the PRF-mediated transcriptional activation of the cMYC promoter by these viral oncoproteins as described in this paper. In contrast, our findings that vIRF (1–3) and EBNA2 (4) interact with p300 and CBP have been shown independently by others. We can no longer support our conclusion of specific viral oncoprotein activation of the cMYC promoter through the PRF element. We regret the confusion that this may have caused.”
References
- 1.Li M, Damania B, Alvarez X, Ogryzko V, Ozato K, Jung J U. Mol Cell Biol. 2000;20:8254–8263. [Google Scholar]
- 2.Burysek L, Yeow W S, Lubyova B, Kellum M, Schafer S L, Huang Y Q, Pitha P M. J Virol. 1999;73:7334–7342. doi: 10.1128/jvi.73.9.7334-7342.1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Lin R, Genin P, Mamane Y. Oncogene. 2001;20:800–811. doi: 10.1038/sj.onc.1204163. [DOI] [PubMed] [Google Scholar]
- 4.Wang L, Grossman S R, Kieff E. Proc Natl Acad Sci USA. 2000;97:430–435. doi: 10.1073/pnas.97.1.430. [DOI] [PMC free article] [PubMed] [Google Scholar]