(Chem. Biol. 21, 453–458; April 24, 2014)
This article has been retracted at the request of the authors.
This article describes the structure of the HER3 pseudokinase domain with bosutinib and finds that bosutinib potentiates allosteric activity of the HER3 pseudokinase. Following an independent investigation by the US Office of Research Integrity (ORI), it was concluded that the first author, Peter Littlefield, engaged in data manipulation and alteration, and it was found that some of the data points in Figures 3C, 4A, and 4B had been changed from the original values. The error bars in Figure 4A were also affected (the full report can be found here: https://ori.hhs.gov/content/case-summary-littlefield-peter). Although these manipulations do not change the major contributions of this paper, given that data in the published paper has been manipulated and the first author engaged in misconduct, we have no other recourse but to retract the paper. We apologize to the research community for the inconvenience.