Table 2.

Clinical and Demographic Characteristics of CD Patients Stratified by Core NADPH Oxidase Gene Mutation Carriage

	No mutation n=199	Mutation n=29
Age-of-onset (years)	9(1–15)	9(5–12)
Male	120(60)	18(62)
White	158(88)	24(86)
CYBA Y72H homozygote	79(40)	13(45)
Ileal location	29(15)	6(21)
Colon-only location	45(24)	7(25)
Ileo-colonic location	114(61)	15(54)
Disease duration (months)	36(36–156)	36(36–137)
Perianal disease	15(8)	8(28)***
Stricturing Behavior	17(9)	8(28)**
Penetrating Behavior	7(4)	2(7)
Abdominal Surgery	17(9)	9(31)***

No mutation: no variants shown in Table 1 except for CYBA Y72H homozygote; Mutation: carriage of 1–3 NADPH oxidase gene variants indicated in Table 1. Data are shown as median (range) or n (%).

^**p<0.01,

^***p<0.001 by chi2