TABLE 2.

Summary of Strength of Evidence and Effect Estimate for Clinical Research Question 1

Instrument (Dimension Assessed)	Validity (ie, Correlation With Other Measures of Cough)	Reliability		Responsiveness	Citations
		Internal Consistency (Cronbach α)	Repeatability
LCQ (severity/QoL)	High SOE 17 studies; 1,191 subjects Range of r = 0.93-0.93	High SOE 4 studies; 430 subjects Range of r = 0.77-0.93	High SOE 2 studies; 256 subjects Range of r = 0.86-0.92	High SOE 12 studies; 862 subjects Range of ES = 0.84-19.5	20, 24, 31, 32, 34, 36, 40, 42-56
CQLQ and ACOSa (severity/QoL)	High SOE 6 studies; 360 subjects Range of r = 0.24-0.79	Low SOE 2 studies; 208 subjects Range of r = 0.63-0.92	Low SOE 2 studies; 76 subjects Range of r = 0.75-0.93	Moderate SOE 8 studies; 484 subjects Range of MID = 10.6-21.9	28, 39, 41, 53, 56-59
PC-QOL (severity/QoL)	Moderate SOE 4 studies; 593 subjects Range of r = 0.01-0.70	Moderate SOE 3 studies; 247 subjects Range of r = 0.56-0.91	Insufficient SOE 1 study; 43 subjects Range of r = 0.40-0.51	Moderate SOE 4 studies; 519 subjects Range of ES = 0.32-0.41	60-62, 99
Electronic recording devices (frequency)	High SOE 23 studies; 774 subjects Range of r = 0.89-0.99	NA	Moderate SOE 6 studies; 239 subjects Range of r = 0.8-1.0	Low SOE 2 studies; 129 subjects Detected change with treatment	19, 21, 22, 24, 29, 35, 43-45, 48, 49, 59, 62-92, 100
Visual analog scales (severity/QoL)	Insufficient SOE 13 studies; 638 subjects No summary measure	NA	Insufficient SOE 1 study; 54 subjects Range of r = 0.71-0.78	Moderate SOE 6 studies; 250 subjects Detected change with treatment	14, 16, 22, 28, 35, 51, 57, 92-98

ACOS = Adverse Cough Outcome Survey; CQLQ = Cough-Specific Quality of Life Questionnaire; ES = effect size; LCQ = Leicester Cough Questionnaire; MID = minimal important difference; NA = not applicable; PC-QOL = Parent Cough-Specific Quality of Life Questionnaire; QoL = quality of life; SOE = strength of evidence.

^aThe ACOS has been revised and replaced by the CQLQ.