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. 2018 May 14;7:e32919. doi: 10.7554/eLife.32919

Figure 5. Tumor-derived CSF-1 is required for TAM RAE-1δ expression in vivo.

Figure 5.

(A) RAE-1δ expression on TAMs in established B16 or B16-Csf1-KO tumors. (B) RAE-1δ on TAMs in mice with established B16 tumors or tumors of a second clone of B16-Csf1-KO cells. (C) RAE-1δ on TAMs in mice with established B16, B16 Csf1-KO, or B16 Csf1-KO tumors in which CSF-1 expression had been restored by transduction (add-back tumors). (D) RAE-1δ on TAMs in mice with established RMA-S or RMA-S-Csf1-overexpressing tumors. Statistical significance was determined using one-way ANOVA with Bonferroni post-tests (C) or a two-tailed unpaired Student t test (A, B, D). Data represent means ±SEM, and are representative of 2–4 independent experiments.