Fig. 4. Chi3l1 production is dependent on T cell activity.

Male WT mice were orally treated with a T cell inhibitor FK506 at 1h prior to Con A administration. (A) Hepatic mRNA expression levels of Chi3l1, IFN-γ and TNF-α were measured at 3h post-Con A by qRT-PCR. (B–C) Protein levels of Chi3l1 in the liver (B) and serum (C) were measured by ELISA (n=3–5 mice per group). P values are as indicated. One-way ANOVA was performed in A–C.