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. 2018 May 2;145(9):dev159426. doi: 10.1242/dev.159426

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© 2018. Published by The Company of Biologists Ltd

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Fig. 1. — Schematic phylogeny of proneural bHLH genes. The relationships and ancestry of extant proneural bHLH genes in vertebrates and Drosophila (Simionato et al., 2007). Each color represents a related subfamily. The most ancient divergence is thought to be between Achaete/Scute-like genes and Atonal/Neurogenin/Neurod-like genes. The divergence of Atonal/Neurod-like and Neurog-like genes predates the vertebrate-insect divide, but the Atonal/Neurod family diverged within the chordate lineage. Achaete/Scute-like genes diversified within insects, including a recent triplication in the lineage leading to Drosophila (Negre and Simpson, 2009).