New diagnoses of cancer were modeled as a time-dependent exposure. Participants who developed cancer during study follow-up contributed follow-up time to the noncancer group before their cancer diagnosis and to the cancer group after their diagnosis. Follow-up day 0 refers to the date of the baseline REGARDS study visit for participants without cancer, and to the date of cancer diagnosis for participants who developed cancer. Follow-up was censored when participants experienced stroke or TIA, withdrew from the REGARDS study, left Medicare insurance coverage, or on December 31, 2014. The inset shows the same data on a magnified x-axis up to 360 days of follow-up. REGARDS = Reasons for Geographic and Racial Differences in Stroke.