Table 3. Prognostic factors of ESCC according to univariate and multivariate analyses.

Variable	Univariate		Risk ratio	Multivariate
	5-year survival rate (%)	p value		95% CI	p value
Gender
Male	67.60	0.5737
Female	76.19
Age
<65 years	65.91	0.6607
≥65 years	73.23
Tumor size
<50 mm	68.36	0.7706
≥50 mm	70.83
Histological type
Well-/moderately differentiated SCC	70.91	0.5023
Poorly differentiated SCC	63.73
Lymphatic invasion
Negative	77.04	0.1597
Positive	61.66
Venous invasion
Negative	78.77	0.0349*	Ref		0.0127#
Positive	55.38		3.9366	1.3404–12.3847
pT
pT1	84.21	0.0107*	Ref		0.2041
pT2-3	56.72		2.4893	0.6312–13.6307
pN
pN0	80.89	0.0944	Ref		0.1658
pN1-3	59.65		2.3638	0.7141–9.8557
pStage
pStage 0–I	87.50	0.0607	Ref		0.6366
pStage II–IV	61.99		1.7698	0.1486–18.3995
AE2 staining score in WT
High	73.19	0.5416
Low	64.97
AE2 staining score at the IF
High	79.40	0.0388*	Ref		0.0326#
Low	53.86		3.2117	1.1014–9.8567

SCC: squamous cell carcinoma; pT: pathological T stage; pN: pathological N stage; pStage: pathological stage; Ref: referent.

^*p < 0.05: Log-rank test.

^#p < 0.05: Cox's proportional hazards model; 95% CI: 95% confidence interval.