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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Shock. 2018 Jul;50(1):5–13. doi: 10.1097/SHK.0000000000001093

Figure 1. Metabolomics and its relationship to the Clinical Situation.

Figure 1

Flow of biochemical information proceeds from the genome through the transcriptome, to the proteome and finally to the metabolome before presenting as the phenome (clinical situation). The metabolome thus constitutes the final integrated response from the genome, transcriptome and the proteome. It is also the last of the biochemical hierarchies before the phenome that manifests as the clinical situation. Clinical situation is in a large part a reflection of the accumulated changes of the metabolome. As such, presentation of the clinical situation is preceded by marked and quantitatively detectable changes in the metabolome which can act as early biomarkers for the clinical trajectory of trauma patients.