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. 2018 Apr 18;8(11):2939–2953. doi: 10.7150/thno.24015

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(A) Pharmacokinetic profiles of DOX after intravenous administration of different DOX formulations (mean±SD, n = 4). (B) In vivo fluorescence images of the MCF-7/ADR tumor-bearing mice at 0.5, 1, 2, 6, 12 and 24 h after i.v. injection of ^SOHNP_Ce6/DOX or HNP_Ce6/DOX. The tumor site was circled with a white line. Semiquantitative biodistribution of ^SOHNP_Ce6/DOX (C) and HNP_Ce6/DOX (D) in various organs at 24 h determined by the Ce6 fluorescence intensity. The data are shown as the mean±SD.