Table 1.

Estimated yearly percentage point change in share of total drug sales represented by each drug category* and according to region of origin

Variables	Prescription drugs					Illicit opioids
	Sedatives	Opioids	Steroids	Stimulants	Other
Within US
Before change:
β coefficient	4.468	2.383	−0.789	1.914	−5.904	10.027
SE	2.955	4.002	1.080	2.106	5.585	4.899
P value	0.13	0.55	0.47	0.36	0.29	<0.05
After change:
β coefficient	0.797	3.946	−0.166	−0.197	0.948	−4.185
SE	0.937	1.269	0.343	0.668	0.618	2.042
P value	0.40	<0.01	0.63	0.77	0.13	<0.05
Outside US
Before change
β coefficient	1.725	1.598	0.300	−0.460	0.456	5.242
SE	3.419	1.323	0.871	1.015	0.515	1.789
P value	0.61	0.23	0.73	0.65	0.38	<0.001
After change:
β coefficient	−1.496	−0.162	−0.235	0.218	−0.166	−0.679
SE	0.898	0.348	0.229	0.267	0.204	0.470
P value	0.10	0.64	0.31	0.42	0.42	0.15

^*Coefficients were estimated on a daily percentage rate basis and converted to a rate over a full year (multiplying by 365) to aid interpretation.