Table 1.
Baseline (Year 20 Exam) Characteristics by Quartile of C-terminal Fibroblast Growth Factor-23
| Plasma C-Terminal Fibroblast Growth Factor-23 (RU/ml) | ||||||
|---|---|---|---|---|---|---|
|
|
||||||
| Characteristics | Overall | 29.8–62.0 | 62.1–77.0 | 77.1–103.2 | ≥103.3 | P Value |
| N | 1758 | 439 (25.0%) | 437 (24.9%) | 443 (25.2%) | 439 (25.0%) | |
| Age, years | 45.0 ± 3.7 | 44.9 ± 3.6 | 44.9 ± 3.6 | 45.2 ± 3.6 | 44.8 ± 3.8 | 0.8809 |
| Female | 1017 (57.8%) | 223 (50.8%) | 209 (47.8%) | 238 (53.7%) | 347 (79.0%) | <.0001 |
| Black | 648 (36.9%) | 169 (38.5%) | 141 (32.3%) | 149 (33.6%) | 189 (43.1%) | 0.1458 |
| Education, years | 15.4 ± 2.6 | 15.5 ± 2.6 | 15.7 ± 2.6 | 15.3 ± 2.5 | 15.1 ± 2.6 | 0.0036 |
| BMI, kg/m2 | 27.7 ± 6.2 | 27.0 ± 7.1 | 27.4 ± 5.5 | 28.1 ± 5.5 | 28.3 ± 6.3 | 0.0003 |
| Physical Activity Score* | 367.2 ± 285.2 | 383.0 ± 265.6 | 383.2 ± 291.8 | 371.4 ± 293.6 | 331.2 ± 286.7 | 0.0061 |
| Smoking Status | 0.0002 | |||||
| Former | 349 (20.0%) | 81 (18.6%) | 84 (19.3%) | 102 (23.2%) | 82 (19.0%) | |
| Current | 287 (16.5%) | 58 (13.3%) | 58 (13.3%) | 80 (18.2%) | 91 (21.1%) | |
| Alcohol, ml/day | 10.2 ± 19.4 | 11.8 ± 25.0 | 11.5 ± 20.1 | 9.8 ± 16.2 | 7.6 ± 14.5 | 0.0006 |
| Triglycerides, mg/dL | 99.0 ± 66.7 | 90.7 ± 57.5 | 104.4 ± 79.2 | 103.5 ± 69.0 | 97.5 ± 57.6 | 0.1710 |
| HDL cholesterol, mg/dL | 55.5 ± 16.6 | 56.6 ± 15.8 | 54.8 ± 17.8 | 53.9 ± 16.0 | 56.8 ± 16.7 | 0.9090 |
| Triglycerides/HDL Ratio | 1.5 (1.0–2.5) | 1.3 (0.9–2.1) | 1.6 (1.0–2.8) | 1.6 (1.0–2.7) | 1.5 (0.9–2.5) | 0.3075 |
| Glucose, mg/dL | 95.4 ± 15.5 | 94.6 ± 15.4 | 94.8 ± 10.9 | 96.7 ± 14.6 | 95.4 ± 19.7 | 0.2191 |
| Diabetes | 71 (4.1%) | 12 (2.7%) | 15 (3.4%) | 19 (4.3%) | 25 (5.7%) | 0.0209 |
| eGFR, ml/min/1.72m2 | 97.7 ± 16.0 | 99.6 ± 15.7 | 97.1 ± 15.6 | 95.2 ± 15.7 | 98.8 ± 16.8 | 0.2254 |
| eGFR < 60 | 2 (0.1%) | 1 (0.2%) | 0 (0.0%) | 0 (0.0%) | 1 (0.2%) | 0.9983 |
| Urine ACR, mg/g | 4.1 (2.9–6.1) | 4.1 (2.8–5.6) | 3.9 (2.7–5.7) | 4.0 (2.9–6.3) | 4.4 (3.1–6.9) | <.0001 |
| Urine ACR ≥ 30 | 61 (3.6%) | 10 (2.3%) | 10 (2.3%) | 14 (3.2%) | 27 (6.5%) | 0.0009 |
| SBP, mmHg | 109.4 ± 9.3 | 109.9 ± 9.3 | 109.4 ± 9.3 | 109.6 ± 9.3 | 108.7 ± 9.3 | 0.0918 |
| DBP, mmHg | 67.1 ± 7.2 | 67.0 ± 7.0 | 66.9 ± 7.3 | 67.5 ± 7.3 | 67.1 ± 7.3 | 0.6095 |
Values are expressed as n (%), mean (SD) and median (25th – 75th percentile). P values are for trend.
*
Total Physical Activity Score in exercise units.
BMI, body mass index; eGFR, estimated glomerular filtration rate; HDL, high density lipoprotein; ACR, albumin to creatinine ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure.