IMMUNOLOGY AND INFLAMMATION Correction for “Revealing the specificity of regulatory T cells in murine autoimmune diabetes,” by Allyson Spence, Whitney Purtha, Janice Tam, Shen Dong, Youmin Kim, Chia-Hsin Ju, Teague Sterling, Maki Nakayama, William H. Robinson, Jeffrey A. Bluestone, Mark S. Anderson, and Qizhi Tang, which was first published April 30, 2018; 10.1073/pnas.1715590115 (Proc Natl Acad Sci USA 115:5265–5270).
The authors note that Fig. 4 appeared incorrectly. The corrected figure and its legend appear below.
Fig. 4.
Insulin-specific Tregs in NOD mice. (A) Representative contour plots of pooled insulin B:9–23 tetramers p8G and p8E staining versus control HEL tetramer staining in islet Tconv cells (Upper) and Tregs (Lower). Cells were gated as live CD45+Thy1.1+CD8− and Foxp3+(Tregs) or Foxp3− (Tconv cells). Results are representative of at least eight mice analyzed in three independent experiments. (B) Quantification of insulin tetramer staining in islet Tconv cells and Tregs. Each pair of connected circles represents one mouse, and the mice (n = 24) are grouped according to age. Results shown are a summary of six independent experiments. Statistical significance was determined using a paired Student’s t test, and P values are listed at the top of the groups. (C) Total number of insulin tetramer-positive Tregs and Tconv cells from islets. Results shown are a summary of three independent experiments. Statistical significance was determined using a paired Student’s t test; *P < 0.05. (D) Nur77GFP MFI of insulin tetramer-positive and -negative Tregs in islets. Results shown are a summary of three independent experiments. Statistical significance was determined using a paired Student’s t test; **P < 0.001.