1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593, Singapore
2Natural Products Research Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do 25451, Republic of Korea
3Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
4Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
5Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 117594, Singapore
6Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
7Division of Neurology, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore
8Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, USA
9Center for Blood Brain Barrier Research, School of Pharmacy, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
10Department of Neurological Surgery, University of Wisconsin, Madison, WI 53792, USA
11Department of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, 3086 VIC, Australia
12Intramural Research Program, Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224, USA
13Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
14School of Pharmacy, Sungkyunkwan University, Suwon, 16419 Republic of Korea
15Neurobiology/Ageing Programme, Life Sciences Institute, National University of Singapore, 117456, Singapore
✉To whom correspondence should be addressed at: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 2 Medical drive, Level 4, Blk MD9, 117593, Singapore. Tel: +65 66013506; Fax: +65 67788161; Email: phstva@nus.edu.sg