Table 1. Univariate Cox proportional-hazards regression analysis of factors influencing overall and disease specific survival.
| Groups | n (%) | Overall survival | Disease survival | |||
|---|---|---|---|---|---|---|
| HR (95% CI) |
P-value | HR (95% CI) |
P-value | |||
| FZD5 | High | 200 (50) | 0.889 (0.95-3.39) | 0.534 | 1.795 (0.95-3.39) | 0.079 |
| Low | 200 (50) | 1.124 (0.30-1.05) | 0.557 (0.30-1.05) | |||
| RYK | High | 200 (50) | 0.957 (0.66-1.39) | 0.818 | 0.877 (0.46-1.66) | 0.685 |
| Low | 200 (50) | 1.045 (0.72-1.52) | 1.140 (0.60-2.15) | |||
| RYK ICD | High | 200 (50) | 1.159 (0.80-1.68) | 0.434 | 0.774 (0.41-1.46) | 0.434 |
| Low | 200 (50) | 0.863 (0.59-1.25) | 1.291 (0.68-2.44) | |||
| WNT5A and FZD5 | WNT5A High FZD5 High |
114 (28.5) | 0.953 (0.59-1.55) | 0.845 | 2.430 (1.05-5.61) | 0.049 |
| WNT5A Low FZD5 Low |
114 (28.5) | 1.049 (0.65-1.71) | 0.411 (0.18-0.95) | |||
| WNT5A High FZD5 Low |
86 (21.5) | 1.088 (0.61-1.95) | 0.775 | 0.504 (0.18-1.39) | 0.202 | |
| WNT5A Low FZD5 High |
85 (21.25) | 0.919 (0.51-1.65) | 1.984 (0.72-5.46) | |||
| WNT5A and RYK | WNT5A High RYK High |
111 (27.75) | 1.044 (0.62-1.75) | 0.872 | 1.301 (0.58-2.95) | 0.530 |
| WNT5A Low RYK Low |
114 (28.5) | 0.958 (0.57-1.61) | 0.769 (0.34-1.74) | |||
| WNT5A High RYK Low |
111 (27.75) | 1.355 (0.80-2.29) | 0.247 | 1.190 (0-49-2-87) | 0.695 | |
| WNT5A Low RYK High |
89 (22.25) | 0.738 (0.44-1.25) | 0.840 (0.35-2.03) | |||
| WNT5A and RYK ICD | WNT5A High RYK ICD High |
96 (24) | 1.191 (0.69-2.07) | 0.529 | 1.142 (0.45-2.88) | 0.776 |
| WNT5A Low RYK ICD Low |
96 (24) | 0.840 (0.48-1.46) | 0.876 (0.35-2.21) | |||
| WNT5A High RYK ICD Low |
104 (26) | 0.896 (0.54-1.49) | 0.671 | 1.759 (0.73-4.23) | 0.221 | |
| WNT5A Low RYK ICD High |
104 (26) | 1.116 (0.67-1.85) | 0.569 (0.24-1.37) | |||
| FZD5 and RYK | FZD5 High RYK High |
133 (33.25) | 0.887 (0.55-1.43) | 0.620 | 1.742 (0.73-4.19) | 0.225 |
| FZD5 Low RYK Low |
133 (33.25) | 1.127 (0.70-1.81) | 0.574 (0.24-1.38) | |||
| FZD5 High RYK Low |
67 (16.75) | 0.979 (0.54-1.78) | 0.945 | 2.458 (0.98-6.20) | 0.075 | |
| FZD5 Low RYK High |
67 (16.75) | 1.021 (0.56-1.86) | 0.407 (0.16-1.03) | |||
| FZD5 and RYK ICD | FZD5 High RYK ICD High |
86 (21.5) | 1.125 (0.61-2.08) | 0.705 | 2.091 (0.67-6.49) | 0.217 |
| FZD5 Low RYK ICD Low |
86 (21.5) | 0.889 (0.48-1.64) | 0.478 (0.15-1.48) | |||
| FZD5 High RYK ICD Low |
114 (28.5) | 0.798 (0.78-2.01) | 0.338 | 1.973 (0.91-4.26) | 0.099 | |
| FZD5 Low RYK ICD High |
116 (29) | 1.253 (0.50-1.28) | 0.507 (0.24-1.10) | |||
Abbreviations: CI, Confidence interval; FZD, Frizzled; HR, Hazard ratio; ICD, Intracellular domain; n, frequency; RYK, Related to receptor tyrosine kinase.