Abstract
We present the case of a 10-year old patient from southeastern Ontario with severe bilateral facial palsy. MRI was performed that showed extensive symmetric enhancement of cervical cranial nerve roots and multiple cranial nerves (III, V, VI, VII, VIII, X and XII). Lumbar puncture was performed that revealed pleocytosis and elevated proteins in the cerebrospinal fluid. Serology confirmed the diagnosis of neuroborreliosis. The patient was treated with a 4-week course of IV ceftriaxone, following which he returned to baseline.
Keywords: Lyme disease, Neuroborreliosis, Facial nerve palsy, Cranial neuropathies
A previously healthy 10-year old boy presented in late August with a one-day history of bilateral facial palsy and an otherwise normal neurological examination. Three weeks prior to presentation, he experienced an evanescent rash on his chest with a spike of fever. While the family was aware of the presence black-legged ticks in their local area located in southeastern Ontario, the family and child denied any recent history of tick bite.
MRI of the brain was performed and revealed bilateral symmetric enhancement of cervical cranial nerve roots and multiple cranial nerves including the oculomotor (III), trigeminal (V), abducens (VI), facial (VII), vestibulo-cochlear (VIII), vagus (X) and hypoglossal (XII) (Fig. 1). Cerebrospinal fluid testing revealed a white blood cell count of 133 cells/μL (81% lymphocytes, 13% neutrophils). CSF protein was elevated at 177 mg/dL (normal < 60 mg/dL) and glucose was 43.2 mg/dL (normal 45–79.3 mg/dL) with a serum glucose of 91.9 mg/dL. Bacterial culture plus molecular testing for herpes simplex virus and enterovirus were negative. Blood was also sent for serologic testing for various viral and bacterial infections.
Fig. 1.
Post-gadolinium axial SPGR images demonstrate multiple enhancing nerves including a) ventral and dorsal cervical nerve roots b) CN VII/VIII in acoustic canal and CN VI (cistern) c) CN V (cistern) d) bilateral CN VI.
Methylprednisolone (30 mg/kg/day for 5 days) was administered for a presumed diagnosis of a neuroinflammatory disorder and, after no improvement in the facial palsy was seen, was followed by IVIG (2 g/kg). On day 6, initial serology results came back positive for Lyme IgG and IgM by Western blot and a diagnosis of neuroborreliosis or early-disseminated Lyme disease with neurological involvement was made. The patient received a 4-week course of IV ceftriaxone (75 mg/kg/day) following which he returned to his baseline condition with no ongoing palsy.
Lyme disease is the most common tick-borne infection in North America and is caused by the spirochete Borrelia burgdorferi (1,2). Frequently associated neurological complications of its early disseminated stage include unilateral facial palsy and aseptic meningitis (3,4). Rarely, multiple cranial nerve involvement is seen (5). In this case, multiple cranial nerve involvement on MRI was unexpected, and suggests the need for careful radiological evaluation of the whole neuraxis, including cranial nerves, in cases of CNS lyme disease.
Declaration of interests
None.
Footnotes
Consent for this publication was obtained from the patient and his parents.
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