Fig. 6.

Multimodal comparative analysis demonstrates significance of the 5 site-gene panel. (a) Comparing 5 site-gene panel (grey bars) to commonly used methods, including differential methylation (black bars), differential expression (red bars),Pearson correlation between methylation and expression (pink bars), top 5 differentially methylated sites (dark red), and top 5 differentially expressed genes (brown) through log-rank p-value, hazard ratio and concordance index. * indicates statistically significant changes (log-rank p = 0.019; HR p = 0.03; c-index p = 0.0001) (b) Random models to evaluate the ability of the 5 site-gene pairs chosen at random to separate patients into groups with different treatment response. Distributions of log-rank p-values from the random models indicate the significance of the predictive ability of our identified 5 site-gene panel. (c) Robustness analysis measuring predictive ability of the identified 5 site-gene panel across increasing FP and FN rates. (d) Multivariable Cox proportional hazard model demonstrates that commonly used prognostic clinical variables do not predict ADT response and do not affect predictive ability of the identified panel (Wald test Cox p-values indicated).