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The classical pathway of melatonin biosynthesis in vertebrates. Red arrows emphasize the four melatonin synthetases. The dashed box marks the main step involved in our present study. Abbreviations: AAAD, l-aromatic amino acid decarboxylase; AANAT, aralkylamine N-acetyltransferase; ASMT: acetylserotonin-O-methyltransferase; 5-HT, 5-hydroxytryptamine; 5-HTP, 5-hydroxytryptophan; MT, melatonin; NAS: N-acetylserotonin; TPH, tryptophan hydroxylase; TRP, tryptophan.
