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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Drug design of multitarget compounds 1–5, which were designed from pharmacophore extraction and reorganization from known modulators of four targets: GPR40, PPARγ, GLUT-4, and AKR1B1.