Table 2.
O-phosphotransferase (APH)-modifying enzymes.
| Enzyme | Resistance Profile | Bacterial Source | Pdb | |
|---|---|---|---|---|
| APH(3′) | I (a–d) | K, Ne, R, L, P | Acinetobacter baumannii | 4FEV |
| II | K, Ne, B, P, R | Stenotrophomonas maltophilia | ||
| III (a–b) | K, Ne, P, B, L, R, B, A, I | |||
| IV | K, Ne, B, P, R | |||
| V | Ne, P, R | |||
| VI | K, Ne, P, R, B, A, I | Bacillus circulans | ||
| APH(2″) | I-a | K, G, T, S, D | ||
| I-(b,d) | K, G, T, N, D | Escherichia coli | 4DCA | |
| II-(a–b) | K, G, T | Enterococcus faecium | 3HAM, 3HAV | |
| IVa | G, K, S | Enterococcus cassaliflavus | 5C4K, 5C4L, 4N57, 4DT8, 4DT9, 4DTA, 4DTB, 3SG8, 3SG9 | |
| APH(3″) | I (a–b) | St | Acinetobacter baumannii | 4EJ7, 4FEU, 4FEV, 4FEX, 4FEW |
| III a | St | Enterococcus faecalis | 2BKK | |
| APH(7) | I a | H | Streptomyces hygroscopicus | |
| APH(4) | I-(a–b) | H | Escherichia coli | 3W0O, 3TYK, 3W0M, 3W0N |
| APH(6) | I-(a–d) | St | Streptomyces griseus | |
| APH(9) | I-(a–b) | Sp | Legionella pneumophila | 3I0O, 3I0Q, 3I1A, 3Q2M |
Abbreviations: A, amikacin; D, dibekacin; H, hygromycin; I, isepamicin; G, gentamicin; K, kanamycin; L, lividomycin; N, netilmicin; Ne, neomycin; P, paromomycin; R, ribostamycin; S, sisomicin; T, tobramycin; Sp, spectinomycin; St, streptomycin.