Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun 11;32:9–20. doi: 10.1016/j.ebiom.2018.05.035

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 1 — Peritoneal macrophages from old mice exhibit quantifiable signs of aging. (a) Aged peritoneal macrophages had reduced oxygen consumption rate (OCR) both at baseline (N = 9/group; 2-tailed, unpaired Welch's t-test) and in response to oligomycin (N = 11–12/group; 2-tailed, unpaired t-test) and significantly reduced ATP-linked respiration (b; N = 9/group; 2-tailed, unpaired Welch's t-test). (c) Lipopolysaccharide (LPS)-treated aged peritoneal macrophages also had impaired mitochondrial bioenergetics at baseline (N = 8–12/group; 2-tailed, unpaired Welch's t-test) and significantly reduced ATP-linked respiration (d; N = 6–9/group; 2-tailed, unpaired t-test) compared to LPS-treated young peritoneal macrophages. (e) Aged peritoneal macrophages had increased mRNA expression of the senescence marker p16^INK4a (N = 10/group; 2-tailed, unpaired t-test). Open circles depict individual data points; horizontal lines depict mean ± SEM (a-e) (* P < .05; ** P < .01; *** P < .001; **** P < .0001).