Fig. 6.

Plasma 24-HC levels discriminate age-related macular degeneration (AMD) from physiologic aging. (a) We divided patients into tertiles by plasma 24-HC and by age (i.e., above versus below median age) and found that individuals in the highest tertile of plasma 24-HC who were also above median age (top right) had the highest AMD prevalence. Horizontal dashed grey lines demarcate plasma 24-HC tertiles; the vertical dashed grey line indicates the median age. (b) Receiver operating characteristic (ROC) curve showing plasma 24-HC discriminates between AMD patients and control subjects. (c) We did not observe a statistically significant difference in plasma 24-HC levels in early AMD patients versus advanced neovascular (wet) AMD patients (N = 21 early AMD; 24 wet AMD; 2-tailed, unpaired t-test). Open circles depict individual data points (a, c); horizontal lines depict mean ± 95% confidence intervals (c).