Figure 7.

Tremor and movement-related spiking in Vim in a single neuron. (A) 5 Hz spiking activity is present during a slight rest tremor. When the patient was asked to raise their arm (to begin our experimental protocol), there is a voluntary movement-related kinaesthetic response and an interruption in the 5 Hz tremor-related activity. This is followed by a re-emergence of tremor bursting with the maintenance of a tremorgenic posture (postural tremor). (B) At rest with no tremor, the neuron had irregular tonic firing, and the emergence of 5 Hz bursting was robustly measurable even with the slightest tremor onset.