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. 2018 May 14;8(2):26. doi: 10.3390/biom8020026

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Impact of pravastatin on mRNA expression of several genes involved in different biological processes characteristic of steatohepatitis after exposing HFD zebrafish larvae to a combination of B[a]P and ethanol. mRNA expressions of several genes were evaluated by RT-qPCR (A–C). Zebrafish larvae were fed with HFD from 4 dpf and from 5 dpf, they were either left untreated (C) or treated with co-exposure of 43 mM ethanol and 25 nM B[a]P (BE) until 12 dpf. Both conditions were also treated with 0.5 µM pravastatin as quoted as (C ± pravastatin) and (BE ± pravastatin), respectively. mRNA expressions of genes characteristic of inflammation and cell death (A), hepatotoxicity (B) and general cellular stress response (C) are shown. Data are expressed relative to mRNA level found in HFD control larvae, set at 0 (log 2 change). Values are the mean ± SEM. * Significantly different from HFD control larvae; ^P Significant difference between larvae treated by pravastatin compared to untreated counterparts.