Figure 3.

A, B, Levels of serum CA-125 in patients taking sirolimus. A, Solid red diamonds represent levels of CA-125 prior to sirolimus treatment, and empty red diamonds represent levels following sirolimus treatment. Although a decrease in serum CA-125 levels is associated with sirolimus treatment (P = .002), of the 32 patients taking sirolimus, 17 had normal serum CA-125 levels both prior to and following treatment. Nine patients had many visits with serum CA-125 levels > 65 U/mL prior to and/or following treatment. The arrowhead and line mark the threshold level of 34 U/mL. B, Serum CA-125 levels in these nine patients over time prior to and following the start of sirolimus treatment. See Figure 1 legend for expansion of abbreviation.