Table 1.

Comparison of structural features in pathogenic and non-pathogenic amyloids.

	Protein/Protein Aggregate	β-Solenoid	Parallel in-Register	Steric Zippers		Salt Bridges 2		Hydro-Phobic Core	Symmetry of Proto-Filaments
				Homo-Steric 1	Hetero-Steric 2	Intra-Molecular	Inter-Molecular
Pathogenic proteins	PHF-tau	(partial)	+	1	6	5	2	+	21 screw
	Aβ(1-42)	−	+	1	2	0	2	+	21 screw
	α-synuclein	−	+	1	2	2	2	+	21 screw
	PrPSc	+	−	0	0	unknown	unknown	+	unknown
Non-pathogenic proteins	HET-s	+	−	0	0	3	0	+	N. A.
	Pectate lyase C	+	−	0	0	15	N. A.	+	N. A.

¹ observed at the protofilament interface; ² based on two protofilaments.