Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 15;103(7):1124–1135. doi: 10.3324/haematol.2017.187013

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright© 2018 Ferrata Storti Foundation

Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions:

https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or internal use. Sharing published material for non-commercial purposes is subject to the following conditions:

https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for commercial purposes is not allowed without permission in writing from the publisher.

PMC Copyright notice

Figure 6. — Nav1.8 expression is elevated in Townes HbSS DRG and is ET_A receptor-dependent. (A) Expression of Scn10a mRNA (encoding Nav1.8) and Scn11a mRNA (encoding Nav1.9) in the L3-L4 DRG from HbAA mice and HbSS mice. n=3 mice/genotype. *P<0.05 vs. the corresponding HbAA mice. (B) Effect of hindpaw injection of ABT-627 or vehicle on expression of Nav1.8 protein in the L3-L4 DRG from HbAA mice and HbSS mice. Left: representative Western blots. Right: a summary of densitometric analysis. n=3 mice/group. *P<0.05 vs. the vehicle-treated HbAA mice. (C) Number of Nav1.8-labeled neurons in the L4 DRG from HbAA mice and HbSS mice. Left: representative immunostaining images. Right: a summary of statistical analysis of the number of Nav1.8-labeled neurons. Scale bar: 50 μm. n = 3 mice/genotype. **P<0.01 vs. the HbAA mice.