Table 2.
The Family‐based association test (FBAT) results with a P < .10. Associations of significance are shown in bold
| Trait | #fam | Z | P | Risk (ref) | |
|---|---|---|---|---|---|
| Rs324015 | |||||
| Food allergy | DBPCFC confirmed food allergy | 221 | 2.097 | .036 | A(g) |
| Peanut allergy | DBPCFC confirmed peanut allergy | 122 | 2.365 | .018 | A(g) |
| sIgE | 89 | 2.063 | .039 | A(g) | |
| Severity | 64 | 2.131 | .033 | A(g) | |
| ED | 54 | 2.558 | .011 | A(g) | |
| Cow's milk allergy | DBPCFC confirmed cow's milk allergy | 72 | 1.781 | .075 | A(g) |
| sIgE | 58 | 2.812 | .005 | A(g) | |
| Severity | 43 | 1.693 | .090 | A(g) | |
| Rs1059513 | |||||
| Food allergy | DBPCFC confirmed food allergy | 103 | 2.488 | .013 | A(g) |
| Peanut allergy | DBPCFC confirmed peanut allergy | 60 | 2.412 | .016 | A(g) |
| sIgE | 41 | 2.195 | .028 | A(g) | |
| Severity | 31 | 2.265 | .024 | A(g) | |
| ED | 29 | 2.168 | .030 | A(g) | |
| Cow's milk allergy | Severity | 18 | 2.428 | .015 | A(g) |
| ED | 15 | 2.261 | .024 | A(g) | |
DBPCFC, double‐blind placebo‐controlled food challenge; sIgE, specific IgE (log‐transformed to improve distribution; LN(sIgE+1)); ED, eliciting dose (log‐transformed to improve distribution; LN(ED+1)); #fam, numbers of informative families; Z, Z‐score; P, P ‐value; Risk(ref), risk allele (reference allele).