Correction
Unfortunately, after publication of this article [1], it was noticed that some corrections to Table 2 were not carried out. The corrected Table 2 can be seen below and the original article has also been updated to reflect this.
Table 2.
Characteristics and plasma fatty acid profile of subjects in the highest and lowest tertiles
| n-6 level | n-3 level | SFA/PUFA ratio | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Highest tertile | Lowest tertile | P | Highest tertile | Lowest tertile | P | Highest tertile | Lowest tertile | P | |
| (n 18) | (n 18) | (n 18) | (n 18) | (n 18) | (n 18) | ||||
| Male/female | 5/13 | 5/13 | 3/15 | 5/13 | 5/13 | 6/12 | |||
| Age (years) | 25 (23–33) | 25 (21–29) | 0.31 | 25 (21–31) | 24 (21–28) | 0.80 | 25 (22–29) | 28 (23.0–32.8) | 0.38 |
| BMI (kg/m2) | 22.5 ± 2.9 | 22.6 ± 2.6 | 0.94 | 22.2 ± 2 | 22.7 ± 3.3 | 0.57 | 23.3 ± 2.7 | 22.6 ± 2.6 | 0.41 |
| Total-C (mmol/l) | 4.9 ± 0.9 | 4.7 ± 1.1 | 0.65 | 4.9 ± 1 | 4.9 ± 1 | 0.96 | 4.7 ± 0.8 | 5.0 ± 0.9 | 0.25 |
| LDL-C (mmol/l) | 2.7 ± 0.8 | 2.6 ± 0.9 | 0.79 | 2.6 ± 0.9 | 2.8 ± 0.6 | 0.71 | 2.5 ± 0.6 | 2.8 ± 0.9 | 0.16 |
| HDL-C (mmol/l) | 1.6 ± 0.4 | 1.4 ± 0.3 | 0.15 | 1.6 ± 0.3 | 1.4 ± 0.4 | 0.28 | 1.5 ± 0.4 | 1.6 ± 0.3 | 0.74 |
| TG (mmol/l) | 0.8 (0.6–0.9) | 1.2 (0.9–1.7) | 0.01 | 0.8 (0.6–1.1) | 1.0 (0.7–1.2) | 0.30 | 1.1 (0.8–1.6) | 0.8 (0.6–0.9) | 0.01 |
| Lymphocytes (%) | 38.4 ± 6.8 | 43.0 ± 8.5 | 0.08 | 42.2 ± 10.0 | 37.6 ± 4 | 0.09 | 42.1 ± 8.7 | 37.4 ± 8.4 | 0.11 |
| Monocytes (%) | 8.5 ± 1.8 | 8.1 ± 1.9 | 0.49 | 8.1 ± 1.7 | 8.6 ± 2.3 | 0.42 | 8.8 ± 2.2 | 8.48 ± 2.0 | 0.71 |
| Plasma level of fatty (wt%) | |||||||||
| Total SFA | 29.4 (28.8–30.5) | 32.1 (31.1–33.2) | < 0.01 | 30.7 (29.3–32.3) | 30.8 (29.8–31.8) | 0.78 | 32.6 (31.5–33.2) | 29.1 (28.7–29.5) | < 0.01 |
| Myristic acid (14:0) | 0.6 (0.6–1.0) | 1.0 (0.8–1.2) | < 0.01 | 0.8 (0.6–1.1) | 0.9 (0.7–1.1) | 0.57 | 1.1 (0.9–1.2) | 0.6 (0.6–0.9) | < 0.01 |
| Palmitic acid (16:0) | 20.5 (20.2–21.6) | 23.4 (21.4–24.2) | < 0.01 | 20.9 (20.4–23.7) | 21.5 (20.9–22.6) | 0.39 | 23.9 (21.8–24.5) | 20.4 (20.2–20.7) | < 0.01 |
| Stearic acid (18:0) | 8.1 ± 0.7 | 8.1 ± 1.1 | 0.86 | 8.2 ± 1.1 | 8.0 ± 1.0 | 0.65 | 8.0 ± 1.1 | 7.7 ± 0.8 | 0.37 |
| Total n-6 | 38.6 ± 1.3 | 30.3 ± 2.9 | < 0.01 | 31.0 ± 4.0 | 31.5 ± 4.5 | 0.74 | 30.8 ± 3.4 | 38.0 ± 2.0 | < 0.01 |
| LA (18:2n-6) | 32.3 ± 1.6 | 24.9 ± 2.5 | < 0.01 | 27.8 ± 3.8 | 29.2 ± 4.1 | 0.29 | 24.8 ± 2.5 | 31.8 ± 2.1 | < 0.01 |
| AA (20:4n-6) | 6.2 ± 1.1 | 5.4 ± 0.9 | 0.02 | 5.8 ± 0.7 | 6.2 ± 1.2 | 0.32 | 5.9 ± 1.3 | 6.2 ± 1. 1 | 0.58 |
| Total n-3 | 5.8 ± 2.5 | 7.0 ± 2.3 | 0.12 | 9.0 ± 0.9 | 3.6 ± 0.49 | < 0.01 | 6.1 ± 2.5 | 6.8 ± 2.4 | 0.44 |
| ALA (18:3n- 3) | 0.5 (0.5–0.6) | 0.5 (0.4–0.6) | 0.46 | 0.5 (0.5–0.6) | 0.5 (0.5–0.6) | 0.79 | 0.5 (0.5–0.6) | 0.5 (0.5–0.5) | 0.95 |
| EPA (20:5n-3) | 1.7 (0.6–2.3) | 2.4 (1.8–2.9) | 0.14 | 3.2 (2.8–3.7) | 0.6 (0.5–0.6) | < 0.01 | 2.0 (0.7–2.6) | 2.2 (1.3–3.2) | 0.46 |
| DPA (22:5n-3) | 0.6 ± 0.1 | 0.7 ± 0.2 | 0.26 | 0.8 ± 0.1 | 0.5 ± 0.1 | < 0.01 | 0.6 ± 0.2 | 0.6 ± 0.1 | 0.80 |
| DHA (22:6n-3) | 3.0 (1.9–4.1) | 4.0 (3.1–4.1) | 0.14 | 4.3 (4.1–4.7) | 1.9 (1.8–2.1) | < 0.01 | 3.5 (2.0–4.1) | 3.3 (2.8–4.3) | 0.48 |
| Total PUFA | 43.8 (42.1–47.3) | 38.6 (35.8–39.7) | < 0.01 | 42.2 (39.5–46.7) | 40.4 (37.7–41.5) | 0.05 | 37.8 (35.8–39.1) | 44.6 (43.1–47.3) | < 0.01 |
| SFA to PUFA ratio | 0.7 (0.6–0.7) | 0.8 (0.8–0.9) | < 0.01 | 0.7 (0.6–0.8) | 0.8 (0.7–0.8) | 0.13 | 0.9 (0.8–0.9) | 0.7 (0.6–0.7) | < 0.01 |
Lymphocytes and monocytes are given as percentage of total white cell count. Differences between tertiles were analyzed using the independent samples t test when normally distributed or the Mann-Whitney U test when not normally distributed. P values < 0.05 were considered significant. Values are presented as mean ± SD or medians and 25th–75th percentile
BMI body mass index, Total-C total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, TG triglycerides, SFA saturated fatty acid, LA linoleic acid, AA arachidonic acid, ALA alpha-linolenic acid, EPA eicosapentaenoic acid, DPA docosapentaenoic acid, DHA docosahexaenoic acid, PUFA polyunsaturated fatty acid
Footnotes
The original article can be found online at 10.1186/s12263-018-0600-z
Reference
- 1.Larsen SV, Holven KB, Ottestad I, Dagsland KN, Myhrstad MCW, Ulven SM. Plasma fatty acid levels and gene expression related to lipid metabolism in peripheral blood mononuclear cells: a cross-sectional study in healthy subjects. Genes Nutr. 2018;13:9. doi: 10.1186/s12263-018-0600-z. [DOI] [PMC free article] [PubMed] [Google Scholar]
