Figure 4. The effect of uORF initiation efficiency (t_σ>ε) on stress resistance.

Other parameters of the simulations t_ε>σ=0; L=100; m_σ=0.3; m_ε=0.3. (A, B) Relative (r_out[r_in]/r_out[r_in=0.1]) (A) and absolute (B) changes in the density of ribosomes downstream of a uORF for a range of r_in from 0.1 to 0 for different uORF initiation efficiencies (t_σ>ε). (C) Dependence of the relative (r_out) maximum increase on the uORF initiation efficiency t_σ>ε. (D) Dependence of absolute maximum r_out rate on t_σ>ε. (E, F) Relative (r_out[r_in]/r_out[r_in=0.1]) (E) and absolute (F) changes in the density of ribosomes downstream of a uORF depending on the delay δ_ε, which is the probability that newly formed elongating will move. For no delay, δ_ε=1. Source data for panel (A) are provided in Figure 4—source data 1, for panel (B) in Figure 4—source data 2, for panel (E) in Figure 4—source data 3 and for panel (F) in Figure 4—source data 4.