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. 2018 Jul 3;6:e5094. doi: 10.7717/peerj.5094

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©2018 Jessl et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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Right and left ovary of genetic females of untreated control group (A, B, C) and tamoxifen-treated group (10 µg/g egg; D, E, F). (A, D) Unfixed right (“Or”) and left (“Ol”) ovary (outlined in black) on day 19 of embryonic development. Untreated control females (A) show a regressed right ovary and a well-differentiated left ovary. Tamoxifen-treated females (D) show an unaffected right ovary and a significantly decreased left ovary. (B, E) Histological thin sections (6 µm) of right (“Or”) and left (“Ol”) ovary. Untreated control females (B) show a left ovary of female typical size and structure. The left ovarian cortex (“C”) is well-differentiated and covers almost the whole ovary (except the region close to the mesonephron (“Me”)). Tamoxifen-treated females (E) show a significantly decreased left ovary with an altered distribution of the cortex region (“C”). The left ovary is no longer covered by a continuous cortex but exposes large regions of uncovered medulla, partly resembling a male testis. (C, F) Histological thin sections (6 µm) of the left ovary in close-up. Untreated control females (C) show a well-differentiated continuous ovarian cortex region (“C”) and a loosely arranged medulla (“M”) crossed by lacunar channels (“L”). Tamoxifen-treated females (F) show a discontinuous irregular scattered ovarian cortex region (“C”) with larger regions of uncovered medulla (“M”) crossed by lacunar channels (“L”).