Table 1. Mortality (%) and malformations (%) in chicken embryos after in ovo exposure to fulvestrant (Ful, 0.1, 1, 10 µg/g egg) and EE2 (20 ng/g egg) or co-exposure to all concentrations of fulvestrant and EE2.
| Test substance | Fulvestrant | |||
|---|---|---|---|---|
| ∑ experiments | 1 | |||
| ∑ eggs | 200 | |||
| Group | ∑ eggs | ∑ fertilized eggs | Mortality (%)a | Malformations (%)a |
| NC | 24 | 22 | 18.2 (4) | 0.00 (0) |
| SC | 22 | 20 | 15.0 (3) | 0.00 (0) |
| Ful 0.1 | 22 | 19 | 26.3 (5) | 10.5 (2) |
| Ful 1 | 22 | 22 | 22.7 (5) | 4.55 (1) |
| Ful 10 | 22 | 19 | 31.6 (6) | 5.26 (1) |
| EE2 | 22 | 22 | 45.5 (10) | 4.55 (1) |
| Ful 0.1 +EE2 | 22 | 20 | 35.0 (7) | 10.0 (2) |
| Ful 1 +EE2 | 22 | 22 | 18.2 (4) | 4.55 (1) |
| Ful 10 +EE2 | 22 | 18 | 33.3 (6) | 11.1 (2) |
Notes.
a
The number in parentheses represents the number of affected embryos.
TITLE
- NC
- untreated control
- SC
- solvent control