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. Author manuscript; available in PMC: 2018 Jul 9.
Published in final edited form as: Hepatology. 2016 Jun 3;64(3):853–864. doi: 10.1002/hep.28570

Figure 5.

Figure 5

(A) By 6 hours after the injection of [14C]cholesterol-labeled HDL, cumulative radioactivity recovered in hepatic bile was significantly higher in WT mice than in ABCG5(−/−)/G8(−/−) and ABCG8 (−/−) mice. However, the HDL-derived [3H]sitostanol was found in WT, but not ABCG5(−/−)/G8(−/−) or ABCG8 (−/−) mice. The LXR agonist T0901317 significantly increased (B) mRNA levels and (C) protein concentrations of ABCG5 and ABCG8 in the liver of WT mice. The LXR agonist significantly (D) augmented hepatic cholesterol output and (E) promoted gallstone formation in WT, but not ABCG5(−/−)/G8(−/−) or ABCG8 (−/−) mice.