Fig. 1.

a, b: Serum levels and patterns of blood glucose a and plasma insulin b before and after iv administration at time 0 min of a bolus of dextrose in 4¼–8 year-old postpubertal baboons delivered to mothers untreated (n = 11) or treated in utero with letrozole (n = 9) as described in legend to Table 1. Values are the means ± SE of the average of 1–4 glucose challenge tests performed longitudinally (i.e. every 6–12 months) in each animal at 4¼ to 8 years of postnatal life. c, d: Blood glucose c and plasma insulin d levels, expressed as 1 min peak and 1 min peak minus fasting baseline levels after administration of an iv bolus of dextrose for the baboon offspring in which the patterns of glucose and insulin are shown in Panels A and B. *P = 0.03 vs. untreated. ^#P = 0.08 vs. untreated