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. 2018 Jul 1;5(Pt 4):520. doi: 10.1107/S2052252518006279

Response to comment on ‘Protein crystal lattices are dynamic assemblies: the role of conformational entropy in the protein condensed phase’

Margarita Dimova a, Yancho D Devedjiev a,*
PMCID: PMC6038947  PMID: 30004094

Abstract

A response is given to Nespolo’s comment [IUCrJ (2018), 5, https://doi.org/10.1107/S2052252518006267] about the usage of the the term ‘crystal lattice’ in Dimova & Devedjiev [IUCrJ (2018), 5, 130–140].

Keywords: protein crystals, crystal lattices


Nespolo (2018) analyses our paper (Dimova & Devedjiev, 2018) from the point of view of crystallography that studies the asymmetric unit of the crystals. From this point of view, the crystal lattice is indeed a mathematical abstraction – a three-dimensional array of identical units. We analyze protein crystals as physical objects and demonstrate that the units in the crystal may not be identical in the same volume and at the same time. To the best of our knowledge this is a new concept that has not been proposed before.

References

  1. Dimova, M. & Devedjiev, Y. D. (2018). IUCrJ, 5, 130–140. [DOI] [PMC free article] [PubMed]
  2. Nespolo, M. (2018). IUCrJ, 5, https://doi.org/10.1107/S2052252518006267.

Articles from IUCrJ are provided here courtesy of International Union of Crystallography

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