Sclerosing angiomatoid nodular transformation of the accessory spleen

Abstract

Rationale:

Sclerosing angiomatoid nodular transformation (SANT) is a rare case which usually occurs in spleen, but our case occurs in accessory spleen.

Patient concerns:

We reported a case of a 27 year old man who was identified with an isodense mass in the left abdominal cavity by ultrasonicphysical examination without symptoms. Blood routine and tumor markers (alpha fetal protein, carcinoembryonic antigen, CA19-9, CA125) were normal.

Diagnoses:

The tumor was firstly diagnosed as left abdominal mass and its origin was considered as small intestinal by the radiologist. The pathological diagnosis was the sclerosing angiomatoid nodular transformation (SANT) of the accessory spleen.

Interventions:

Laparoscopic splenectomy is a more reliable method for the treatment of SANT.

Outcomes:

Non-enhanced CT showed iso-intensity lesion of the accessory spleen, and enhanced CT showed progressive enhancement. According to the above characteristics, we should consider the diagnosis of spleen SANT. We reviewed some literatures to summarize the characteristics of SANT.

1. Introduction

Sclerosing angiomatoid nodular transformation (SANT) is a kind of rare benign tumor that occurs in the spleen. Martel et al^[1] first described the disease of SANT in 2004. However, SANT was only a concept of pathological diagnosis, in clinical, the real nature of SANT was not full understood.^[2] The pathogenesis of SANT also remained unclear.^[3] Chang et al^[4] concluded that SANT was considered as a polyclonal and reactive lesion rather than a neoplasm. Most literatures have provided several information about SANT in spleen, while no literature has reported SANT occurring on accessory spleen. In our case, we report a rare case of SANT that occurs in the accessory spleen.

2. Case report

A 27-year-old male was found with an isodense mass in the left abdominal cavity by abdominal ultrasonography during physical examination. He was asymptomatic and blood routine, tumor markers (alpha fetal protein, carcinoembryonic antigen, CA19-9, CA125) were normal. Subsequently, he underwent an abdominal computed tomography (CT) scan. On the abdominal nonenhanced CT scan, a round isodense tumor with calcification was seen in the right front of left kidney and left front of spleen, and it possessed of the size of 5.9 cm × 5.4 cm and CT value of 38 Hounsfield unit (Hu). The boundary between the lesion and the tail of pancreas, left kidney, and spleen was still clear (Fig. 1A). On contrast-enhanced CT, the lesion was slightly and progressively enhanced (CT values of the arterial, venous, and delayed phases were about 51, 55, 66 Hu, respectively) and its density was lower than that of spleen at the same phases (CT values of the arterial, venous, and delayed phases were about 73–109, 94–107, 70–76 Hu, respectively) (Fig. 1B–D). Moreover, we could find an enhanced edge on contrast-enhanced CT (CT values of the arterial, venous, and delayed phases were about 71, 72, 76 Hu, respectively (Fig. 1B: red arrow). The tumor was first diagnosed as left abdominal mass and its origin was considered as small intestinal by the radiologist.

Figure 1.

(A) Nonenhanced computed tomography: An isodense tumor with calcification on accessory spleen. (B–D) Enhanced computed tomography: (B) Arterial phases: enhanced edge (red arrow), (C, D) venous and delayed phases: progressive enhancement.

2.1. Surgical and pathological findings

The electric knife cut the skin into the abdomen, and liver, gallbladder, spleen were normal. During the operation, the mass was located in the lower pole of the spleen measuring 6.0 cm × 6.0 cm with complete capsule. Later, the mass was resected by ultrasonic knife. The mass was off-white and gray red, medium texture. Lesion consisted of spindle cells, which was arranged as nodules. There were splenic sinus structures around the nodules and sinus-like blood vessels in the central of nodules. The pathological diagnosis was the SANT of the accessory spleen (Fig. 2).

Figure 2.

HE × 400: Lesions formed by the spindle cells, arranged in nodular central sinusoidal blood vessels could be seen.

3. Discussion

SANT is a benign tumor of the spleen and usually occurs in middle-aged female. SANT is usually asymptomatic or just along with abdominal pain.^[5] In our case, the patient was a young male without any symptom and the primary site was accessory spleen. Accessory spleen is relatively common, which is known as healthy spleen tissue isolated from spleen and can be seen in 10% to 30% of patients at autopsy. It is clinically important in some patients, although usually asymptomatic and incidentally discovered.^[6] Previous reports about SANT all occurred in the spleen. Our article summarized the characteristics of some SANTs of spleen in Table 1. Nonenhanced CT or magnetic resonance (MR) scan show a round mass with hypodence and clear boundary. On enhanced CT or MR scan, many SANT lesions are exhibited as a “spoked wheel” mode.^[5,7] This “spoked wheel” has been shown on detailed radiological and pathological findings, which is equivalent to the central stellate fiber interstitial fibrillar nodules isolated nodules.^[8] Karaosmanoglu et al^[7] described the SANT's magnetic resonance imaging (MRI) findings at first. They mentioned in their article that the “spoked wheel” images of lesions on T2-weighted images were similar to CT multiphasic imaging. Subsequently, some studies^[1,9–12] have suggested that the MRI features and multiphase CT imaging of “spoked wheel” of SANT may be useful for the diagnosis of SANT. Our patient only underwent CT examination, which showed progressive enhancement, although it had not yet reached the obvious “spoked wheel” pattern, Furthermore, calcification was also observed in previous literature, which is consistent with our case.^[13] In addition, according to the patient's CT angiography images (Fig. 3A, B), we can find that the main feeding artery of the lesion mainly comes from the splenic artery, and it is generally known that the feeding artery of the spleen is the splenic artery, which can provide a diagnostic idea. However, the final diagnosis is still immunohistochemistry but not imaging. The histomorphology and staining profile taken together finally confirmed the diagnosis of SANT.^[14] So far, laparoscopic splenectomy is a more reliable method for the treatment of SANT.^[15] We summarize the case reports in Table 1; most used splenectomy or laparoscopic splenectomy, and the prognosis, follow-up are well without recurrence.

Table 1.

Some SANT characteristics.

Figure 3.

(A) 3D imaging, (B) 2D imaging: The main artery of the tumor was from the splenic artery.

4. Conclusion

On the basis of these characteristics of CT, we conclude that if we find an isodence lesion of the accessory spleen on nonenhanced CT, and show progressive enhancement on enhanced CT, meantime, the main nutritional artery is the splenic artery, diagnosis of SANT in accessory spleen should be taken into account. To summarize, we think that our report may constitute a significant step forward for diagnosis of SANT in accessory spleen and it may provide more therapeutic and prognostic information for clinical management.

Author contributions

Writing – original draft: Miao Niu, Qinhe Zhang.

Writing – review & editing: Ailian Liu, Jingjun Wu, Jinghong Liu.