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. 2018 Jun 26;9(49):29047–29063. doi: 10.18632/oncotarget.25540

Figure 6. Up-regulation of invasion and invadopodia-related genes is correlated with poor OSCC patient disease-free survival.

Figure 6

RNA sequencing data for 519 head and neck squamous cell carcinoma (HNSCC) samples were retrieved from The Cancer Genome Atlas (TCGA) and analyzed with cBioPortal and MATLAB. The analyzed dataset contains mRNA expression Z-scores (RNA-Seq V2 RSEM) computed as the relative expression of an individual gene and tumor to the expression distribution of all samples that are diploid for the gene. Samples were split into high and low expressing groups based upon mRNA expression Z-scores. The Z-score cut-off value for a given gene was defined as that which gave the lowest p-value. (A) Forest plots of top 30 DFS genes obtained by comparing the up-regulated genes that appeared by mRNA sequencing data to TCGA database as above. Kaplan–Meier representation of disease-free survival in 519 HNSCC samples from TCGA database correlated to expression of genes PI3-Kinase subunit delta (B), lactamase B (C), sphingosine-1 phosphate receptor 1 (D), Dysferlin (E), and interferon alpha-inducible protein 27 (F).