In the original article, there was an error in the wording concerning the production of cytokines.
A correction has been made to the section Results, Subsection CCGAD65 Peptide Elicits CD4+ T Cells with a Unique Phenotype and Cytolytic Properties, Paragraph 2:
The phenotype at resting state, 14 days after last stimulation with CCGAD65-loaded APCs, was CD3+CD4+CD8−CD25+CD44+CD62L−CD127−CD27−CD28−, indicative of an effector memory phenotype. Some cells were positive for T-Bet and/or GATA-3, but all were negative for Foxp3. The production of cytokines was essentially Il-4 and low IFN-γ. This distinct phenotype was conserved even when cells were repeatedly stimulated in vitro with the WTGAD65 peptide, suggesting a terminal differentiation. By contrast, the phenotype expressed by CD4+ T cells generated in a similar manner from mice immunized with the WTGAD65 peptide was CD3+CD4+CD8−CD25+CD44+CD62L−CD127highCD27highCD28− (Figure 2B; Figures S3 and S4 in Supplementary Material). Altogether, this indicates that cells generated with a thioreductase-containing peptide are terminally differentiated effector T cells with a memory phenotype.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.
The original article has been updated.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.