Skip to main content
NCBI home page
Food Science and Biotechnology logoLink to Food Science and Biotechnology
. 2016 Aug 31;25(4):1135–1145. doi: 10.1007/s10068-016-0182-8

Hypoglycemic Effects of sesquiterpene lactones from Byrsonima crassifolia

Rosa Martha Pérez Gutiérrez 1,✉, Alethia Muñiz Ramirez 2
PMCID: PMC6049102  PMID: 30263386

Abstract

The novel dimeric guaianolides sesquiterpene lactone Byrsoninas A and B from seed hexane extract of Byrsonima crassifolia were identified. Streptozotocin-induced mildly diabetic and severely diabetic mice were treated with these oral administrations at a dosage of 20 mg/kg of body weight per day for 30 days. Also the protective effect in vitro in RIN-5F cells against oxidative stress was investigated and TNF-α and IL-6 levels were measured. Both Byrsonina types reduced blood glucose, cholesterol, triglyceride, lipoprotein, and transaminase levels and increased HDL-cholesterol, antioxidant enzymes, and TBARS-reactive substance levels. Byrsoninas A and B both improved this glucose metabolism by reducing insulin resistance and by stimulating insulin production due to protection effect for pancreatic β-cells against oxidative stress, lipid abnormalities were reduced and, chronic inflammation responses were alleviated producing a hepatoprotective role.

Keywords: guaianolides, antidiabetic, hyperlipidemia, Byrsonima crassifolia

References

  • 1.Aylin S, Sereften A, Cemal C. Effects of in vivo antioxidant enzyme activities of myrtle oil in norrnoglycaemic and alloxan diabetic rabbits. J. Ethnopharmacol. 2007;110:498–503. doi: 10.1016/j.jep.2006.10.015. [DOI] [PubMed] [Google Scholar]
  • 2.Cheng D. Prevalence, predisposition and prevention of typeIIdiabetes. Nutr. Metab. 2005;18:2–29. doi: 10.1186/1743-7075-2-29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia. 2002;45:85–96. doi: 10.1007/s125-002-8248-z. [DOI] [PubMed] [Google Scholar]
  • 4.Grankvist K, Marklund SL, Taljedal LB. CuZn-superoxide dismutase, Mnsuperoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem. J. 1981;199:393–398. doi: 10.1042/bj1990393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Espana SM, Velez de Marsicovetere PV, Caceres A. Plants used in Guatemala for the treatment of gastrointestinal disorders. Vibriocidal activity of five American plants used to treat diarrhea. Fitoterapia. 1994;65:273–274. [Google Scholar]
  • 6.Bejar E, Malone MH. Chemical screening of Byrsonima crassifolia a medicinal tree from México. Part I. J. Ethnopharmacol. 1993;39:141–158. doi: 10.1016/0378-8741(93)90029-5. [DOI] [PubMed] [Google Scholar]
  • 7.Alves GL, Franco MRB. Headspace gas chromatography-mass spectrometry of volatile compounds in murici (Byrsonima crassifolia) J. Chromatogr. A. 2003;985:297–301. doi: 10.1016/S0021-9673(02)01398-5. [DOI] [PubMed] [Google Scholar]
  • 8.Geiss F, Heinrich M, Hunkler D, Rimplerl H. Proanthocyanidins with (+)-epicatechin units from Byrsonima crassifolia bark. Phytochemistry. 1995;39:635–643. doi: 10.1016/0031-9422(94)00934-L. [DOI] [Google Scholar]
  • 9.Rastrelli L, De Tommasi N, Berger I, Caceres A, Saravia A, De Simona F. Glycolipids from Byrsonima crassifolia. Phytochemistry. 1997;45:647–650. doi: 10.1016/S0031-9422(96)00842-4. [DOI] [Google Scholar]
  • 10.Sannomiya M, Vitor B, Fonseca MA, da Silva Rocha LRM, dos Santos LC, Hiruma-Lirna ARM, Souza BC. Flavonoids and antiulcerogenic activity from Byrsonima crass a leaves extracts. J. Etnopharmacol. 2005;97:1–6. doi: 10.1016/j.jep.2004.09.053. [DOI] [PubMed] [Google Scholar]
  • 11.Aguiar RM, David JP, David JM. Unusual naphthoquinones, catechin and triterpene from Byrsonima microphylla. Phytochemistry. 2005;66:2388–2392. doi: 10.1016/j.phytochem.2005.07.011. [DOI] [PubMed] [Google Scholar]
  • 12.Sannomiya M, Cardoso CRP, Figueiredo ME, Rodrigues CM, Dos Santos LC, Serpeloni FV, Colus IMS, Vilegas W, Varanda EA. Mutagenic evaluation and chemical investigation of Byrsonima intermedia A. Juss. leaf extracts. J. Ethnopharmacol. 2007;112:319–326. doi: 10.1016/j.jep.2007.03.014. [DOI] [PubMed] [Google Scholar]
  • 13.Maldini M, Sosa S, Montoro P, Giangaspero A, Balick MJ, Pizza CD, Loggia R. Screening of the topical anti-inflammatory activity of the bark of Acacia cornigera Willdenow, Byrsonima crassifolia Kunth, Sweetia panamensis Yakovlev and the leaves of Sphagneticola trilobata Hitchcock. J. Ethnopharmacol. 2009;122:430–433. doi: 10.1016/j.jep.2009.02.002. [DOI] [PubMed] [Google Scholar]
  • 14.Ramirez AM, Gutierrez RMP, Cotera LBF. Evaluation of anti-inflammatory activity hexane extract of Byrsonima crassifolia. Altern. Ther. Health M. 2013;19:26–36. [PubMed] [Google Scholar]
  • 15.Silva EM, Souza JNS, Rogez H, Rees JF, Larondelle Y. Antioxidant activities and polyphenolic contents of fifteen selected plant species from the Amazonian region. Food Chem. 2007;101:1012–1018. doi: 10.1016/j.foodchem.2006.02.055. [DOI] [Google Scholar]
  • 16.Martinez-Vazquez M, Gonzalez-Esquinca AR, Cazares LL, Moreno GMN, Garcia-Argaer AN. Antimicrobial activity of Byrsonima crassifolia (L.) H.B.K. J. Ethnopharmacol. 1999;66:79–82. doi: 10.1016/S0378-8741(98)00155-X. [DOI] [PubMed] [Google Scholar]
  • 17.Caceres A, Brenda B, Lopez R, Giron MA, Logemann H. Plants used in Guatemala for the treatment of dermatophytic infections. I. Screening for antimycotic activity of 44 plant extracts, treatment of protozoal infections: Activity of extracts and fractions of five Guatemalan plants against Trypanosoma cruzi. J. Ethopharmacol. 1998;62:107–115. [Google Scholar]
  • 18.Peraza-Sánchez SR, Cen-Pacheco F, Noh-Chimal A, May-Pat F, Sima-Polanco P, Dumonteil E, García-Miss MR, Mut-Martín M. Leishmanicidal evaluation of extracts from native plants of the Yucatan peninsula. Fitoterapia. 2007;78:315–318. doi: 10.1016/j.fitote.2007.03.013. [DOI] [PubMed] [Google Scholar]
  • 19.Perez-Gutierrez RM, Muñiz-Ramirez A, Gomez Gomez Y, Bautista-Ramirez E. Antihyperglycemic, antihyperlipidemic and antiglycation of Byrsonima crassifolia fruits. Plant Food. Hum. Nutr. 2010;65:350–357. doi: 10.1007/s11130-010-0181-5. [DOI] [PubMed] [Google Scholar]
  • 20.de Aluja AS. Laboratory animals and official Mexican norms (NOM-062-ZOO-1999) Gac. Méd. Méx. 2002;138:295–298. [PubMed] [Google Scholar]
  • 21.Zhou J, Zhou S, Zeng S, Zhou J, Jiang M, He Y. Hypoglycemic and hypolipidemic effects of ethanolic extract of Mirabilis jalapa L. root on normal and diabetic mice. 2012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 22.Tahara A, Matsuyama-Yokono A, Nakano R. Hypoglycaemic effects antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic and streptozotocininduced severely diabetic rats. Basic Clin. Pharmacol. 2008;103:560–568. doi: 10.1111/j.1742-7843.2008.00321.x. [DOI] [PubMed] [Google Scholar]
  • 23.Bradford MA. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976;72:248–254. doi: 10.1016/0003-2697(76)90527-3. [DOI] [PubMed] [Google Scholar]
  • 24.Andreasson U, Perret-Liaudet A, van Waalwijk van Doorn LJ, Blennow K, Chiasserini D, Engelborghs S, Fladby T, Genc S, Kruse N, Kuiperij HB, Kulic L, Lewczuk P, Mollenhauer B, Mroczko B, Parnetti L, Vanmechelen E, Verbeek MM, Winblad B, Zetterberg H, Koel-Simmelink M, Teunissen CE. A practical guide to immunoassay method validation. Front. Neurol. 2015;19:176–179. doi: 10.3389/fneur.2015.00179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25.Marina GG, Aldini M, Piccone MN. Fluorescent probes as markers of oxidative stress in keratinocyte cell lines following UVB exposure. Pharmacology. 2000;55:526–534. doi: 10.1016/s0014-827x(00)00037-9. [DOI] [PubMed] [Google Scholar]
  • 26.Sarnek Z. The determination of the stereochemistry of five-mernbered a,ß-unsaturated lactones, with an exomethylene double bond based on the allylic long-range couplings of exomethylene protons. Tetrahedron Lett. 1970;9:671–676. [Google Scholar]
  • 27.Ramesh BK, Maddirala DR, Vinay KK, Shaik SF, Tiruvenkata KEG, Swapna Ramesh B, Rao CA. Antihyperglyeemic and antihyperlipidemic activities of methanol:Water (4:1) fraction isolated from aqueous extract of Syzygiumalternifolium seeds in streptozotocin induced diabetic rats. Food Chem. Toxicol. 2010;48:1078–1084. doi: 10.1016/j.fct.2010.01.029. [DOI] [PubMed] [Google Scholar]
  • 28.Pociot F, Reimers JI, Andersen HU. Nicotinamide—biological actions and therapeutic potential in diabetes prevention. IDIG Workshop, Copenhagen, Denmark, 4-5 December 1992. Diabetologia. 1982;36:574–576. doi: 10.1007/BF02743277. [DOI] [PubMed] [Google Scholar]
  • 29.Ullah OM, Uddin MJ, Hamid K, Kabir S, Azizur Rahman M, Choudhuri MSK. Studies of various biochemical parameters of rat plasma following chronic administration of “Rohitakarista”-An Ayurvedic Formulation. Pak. J. Biol. Sci. 2008;11:2036–2039. doi: 10.3923/pjbs.2008.2036.2039. [DOI] [PubMed] [Google Scholar]
  • 30.Ahmed N. Advanced glycation endproducts-role in pathology of diabetic complications. Diabetes Res. Clin. Pr. 2005;67:3–21. doi: 10.1016/j.diabres.2004.09.004. [DOI] [PubMed] [Google Scholar]
  • 31.Ruge T, Lockton JA, Renstrom F, Lystig T, Sukonina V, Svensson MK, Eriksson JW. Acute hyperinsulinemia raises plasma interleukin-6 in both nondiabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass index. Metab. Clin. Exp. 2009;58:860–866. doi: 10.1016/j.metabol.2009.02.010. [DOI] [PubMed] [Google Scholar]
  • 32.Suzuki M, Mihara M. Adiponecrin induces CCL20 expression synergistically with IL-6 and TNF-a macrophages. Cytokine. 2012;58:344–350. doi: 10.1016/j.cyto.2012.02.009. [DOI] [PubMed] [Google Scholar]

Articles from Food Science and Biotechnology are provided here courtesy of Springer

RESOURCES