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. 2016 Apr 30;25(2):589–594. doi: 10.1007/s10068-016-0082-y

Anti-stress activity of Sargassum polycystum extracts using a cold restraint stress model

Radipta Lailatussifa 1, Amir Husni 1,✉, Agung Endro Nugroho 2
PMCID: PMC6049188  PMID: 30263310

Abstract

Anti-stress effects of polyphenol extracts of Sargassum polycystum were evaluated. Polyphenol extracts of S. polycystum and diazepam were compared for anti-stress activities using a cold restraint animal stress model. S. polycystum extracts were administered orally at dosages of 150 and 450 mg/kg. Diazepam, an anti-stress agent, was used as a standard drug at 0.18 mg/kg p.o. Both dosages of S. polycystum extracts showed good anti-stress effects. Due to cold restraint stress there was an imbalance in levels of biochemical parameters, including glucose, triglycerides, cholesterol, alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate amino transferase (AST), which were near normalized following adminstration of S. polycystum extracts. Polyphenol extracts of S. polycystum at oral dosages of 150 and 450 mg/kg exerted anti-stress effects.

Keywords: anti-stress, Sargassum polycystum extract, polyphenol, marine algae, gastric ulcer

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