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. 2016 Apr 30;25(2):615–621. doi: 10.1007/s10068-016-0086-7

Effects of Allium hookeri root water extracts on inhibition of adipogenesis and GLUT-4 expression in 3T3-L1 adipocytes

Hee Sun Yang 1, Yu Jin Choi 1, Hee Yeon Jin 1, Sang Cheon Lee 1, Chang Ki Huh 1,✉
PMCID: PMC6049204  PMID: 30263314

Abstract

Anti-adipogenic and antidiabetic activities of Allium hookeri root water extracts (ARW) were assessed. Oil Red O staining showed that treatment with ARW caused a dose-dependent reduction in lipid accumulation. ARW was also involved in adipocyte lipolysis via LPL activity, and in the concentration of glycerol in a culture medium. On the basis of the concentration of adipokines following ARW treatment, ARW appeared to inhibit expression of PPAR-γ, to reduce concentrations of leptin and resistin, to increase the concentration of adiponectin, and to inhibit lipid accumulation. ARW modulated adipokine expression associated with insulin resistance and sensitivity. 3T3-L1 adipocytes treated with ARW showed increased GLUT-4 expression with increased glucose uptake into adipocytes. ARW showed effectiveness for improvement of diabetic conditions.

Keywords: Allium hookeri, adipogenesis, GLUT-4, 3T3-L1

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