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. 2018 Jul 20;15:50. doi: 10.1186/s12977-018-0431-4

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — CT-deleted 4-2.J41 Env has altered cell surface antigenicity/conformation. a Schematic of different domains in the C-terminal tail of HIV-1 Env. b FACS based cell surface staining assays of 4-2.J41_WT and 4-2.J41ΔCT₇₁₁ with cleavage non-specific bNAb, VRC01 and non-NAbs, F105, 17b and b6 over a range of antibody concentrations. c FACS based cell surface staining assays of 4-2.J41_WT and 4-2.J41ΔCT₇₁₁ with glycan-dependent, conformational bNAbs, PG9, PG16, PGT121, PGT128. d FACS based cell surface staining assays of 4-2.J41_WT and 4-2.J41ΔCT₇₁₁ with bNAb, VRC01 and trimer-selective, cleavage-specific bNAb, PGT151