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. Author manuscript; available in PMC: 2018 Sep 27.
Published in final edited form as: Biometrics. 2018 Jan 22;74(3):1095–1103. doi: 10.1111/biom.12842

Table 4.

Simulation results. We report the proportion of simulated trials in which N was declared superior (inferior) to C, and the average sample size. The correct decision is indicated in boldface. Reported figures are based on 5,000 simulated trials.

Primary Salvage Average
Design Sup. Inf. Sup. Inf. Sample Size
Scenario 1 (Complete Null)

Traditional 0.022 0.025 0.022 0.025 99.7
Stratified PO 0.022 0.025 0.020 0.025 99.8
Stratified NPO 0.029 0.028 0.029 0.032 99.5

Scenario 2 (Partial Null - PO)

Traditional 0.509 0.000 0.509 0.000 95.5
Stratified PO 0.774 0.000 0.038 0.017 94.9
Stratified NPO 0.763 0.000 0.048 0.022 93.7

Scenario 3 (Partial Null - PO)

Traditional 0.417 0.000 0.417 0.000 96.6
Stratified PO 0.040 0.015 0.784 0.000 96.5
Stratified NPO 0.047 0.016 0.782 0.000 95.4

Scenario 4 (Complete Alternative - PO)

Traditional 0.978 0.000 0.978 0.000 74.7
Stratified PO 0.841 0.000 0.850 0.000 87.4
Stratified NPO 0.842 0.000 0.853 0.000 84.6

Scenario 5 (Partial Null - NPO)

Traditional 0.215 0.001 0.215 0.001 98.5
Stratified PO 0.314 0.001 0.032 0.019 98.9
Stratified NPO 0.347 0.001 0.043 0.025 98.0

Scenario 6 (Partial Null - NPO)

Traditional 0.239 0.001 0.239 0.001 98.3
Stratified PO 0.036 0.019 0.462 0.000 98.7
Stratified NPO 0.042 0.021 0.503 0.000 97.7

Scenario 7 (Complete Alternative - NPO)

Traditional 0.710 0.000 0.710 0.000 92.1
Stratified PO 0.387 0.000 0.528 0.000 96.6
Stratified NPO 0.434 0.000 0.584 0.000 94.8