Figure 1.

Validation and stability of the DNA methylation changes associated with atopic asthma. The strongest DNA methylation changes associated with atopic asthma (rhinovirus + atopic asthma + vs rhinovirus + atopic asthma −) were validated with targeted pyrosequencing (A) at the average age of 5 y and (B) at the average age of 8 y in samples collected from the same children. In addition, to outlier box plots, the distribution of DNA methylation levels of individual CpG sites within the indicated region for each individual is shown in the figure. In addition, median methylation differences and t test P‐values are shown in the figure