Figure 5.

α₁β₃(P301L)γ_2s receptors are less sensitive to GABA activation. (A) Example trace of GABA concentration-response assays (1–3000 μM) for α₁β₃γ_2s and α₁β₃(P301L)γ_2s receptors expressed in HEK293T cells. Scale bars: horizontal = 5 s, vertical = 500 pA. (B) GABA concentration-response curves for α₁β₃γ_2s (solid line, n = 21 cells) and α₁β₃(P301L)γ_2s (dotted line, n = 20 cells) receptors. Points are mean ± SEM and error bars are not shown where bars are smaller than points. The drawn line is a representative fit based on the average GABA concentration responses.