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. Author manuscript; available in PMC: 2018 Dec 7.
Published in final edited form as: Nanoscale. 2017 Dec 7;9(47):18723–18730. doi: 10.1039/c7nr05502a

Fig. 5.

Fig. 5

Ex vivo evaluation of the uptake of MPI contrast agents by tumor xenografts. (a) NIRF images and (b) Representative MPI signal intensities (per tumor mass) of the tumor xenografts excised from mice (mean ± standard deviation; n = 3) injected with Cy5.5-lactoferrin conjugated NPs, with (Mag. + Lact.) and without (Lact. only) using magnetic targeting, compared with Cy5.5-labeled NPs (without any lactoferrin and magnetic targeting) and PBS as controls. Signal intensities were measured using a magnetic particle spectrometer. Significance was confirmed by one-way ANOVA with Bonferroni multiple comparison correction * p<0.05, ** p<0.0005 and *** p<0.0001. In NIRF images brightness is proportional to the uptake of the fluorescently labeled NPs, while in MPI measurements, bars represent MPI signal intensity (dm/dH) only generated from magnetic response of the NPs without any background signal from the tissues.