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. 2018 Feb 15;14(7):1665–1671. doi: 10.1080/21645515.2018.1423928

Willingness to pay for an Ebola vaccine during the 2014–2016 ebola outbreak in West Africa: Results from a U.S. National sample

Julia E Painter a,, Michael E von Fricken a, Suyane Viana de O Mesquita a, Ralph J DiClemente b
PMCID: PMC6067876  PMID: 29333950

ABSTRACT

The 2014–2016 Ebola virus outbreak in West Africa led to advances in the development of vaccines against Ebola. This study examined factors associated with willingness to pay for an Ebola vaccine among a U.S. national sample during the recent Ebola outbreak. From April 30–May 8, 2015, a national survey was conducted using the GfK Group's KnowlegePanel®. Main outcome measures included willingness to pay at least $1; more than $50; and more than $100 for an Ebola vaccine. Analyses were conducted using weighted multivariable logistic regression. Among participants (N = 1,447), 583 (40.3%) would not pay for an Ebola vaccine; 864 (59.7%) would pay at least $1. Among those willing to pay at least $1: 570 (66.0%) would pay $1–50; 174 (20.1%) would pay $51–100; and 120 (13.9%) would pay more than $100. Willingness to pay at least $1 for an Ebola vaccine was associated with international travel; interest in getting an Ebola vaccine; and beliefs that the U.S. government should spend money to control Ebola and assume worldwide leadership in confronting emerging epidemics. Willingness to pay more than $50 was associated with similar variables. Willingness to pay more than $100 was associated with international travel; interest in getting an Ebola vaccine; information seeking; and beliefs that the U.S. government should assume worldwide leadership in confronting emerging epidemics. International travel and interest in an Ebola vaccine were key predictors of willingness to pay across all price points. Understanding willingness to pay for vaccines against emerging infectious diseases remains critical.

KEYWORDS: Ebola, attitudes, beliefs, willingness to pay, vaccine

Introduction

From 2014–2016, West Africa experienced the largest outbreak of Ebola virus disease (Ebola) in history — infecting over 28,000 people and killing over 11,000.1 The severity of this outbreak, declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO) in August of 2014,2 has led to accelerated Ebola vaccine research and clinical trials.3-9 Recently, findings from the rVSV-ZEBOV vaccine phase III clinical trial indicated 100% vaccine efficacy, bringing an Ebola vaccine one-step closer to reality.7 Considered a global priority,6,8 development of an Ebola vaccine would be of significant benefit to people living in West Africa and other regions at increased risk for Ebola virus outbreaks.

An Ebola vaccine might also be of benefit certain groups of people in the United States, such as health care workers treating Ebola patients, personnel assisting with outbreak response, and travelers to Ebola-affected areas. It is unlikely that an Ebola vaccine would greatly benefit the U.S. population in general, as the epidemiological toll of the 2014–2016 Ebola epidemic in the United States was minimal. Yet while only four cases were reported nationally,10,11 the epidemic garnered extensive media coverage, leading to a national contagion of fear.12 The U.S. “Fearbola”13 phenomenon provides a unique opportunity to explore factors that might impact willingness to pay for an Ebola vaccine in the United States.

Willingness to pay for vaccines is an important indicator of public perception and demand,14,15 which has been identified as a major factor in influencing vaccine policy and innovation.16 Thus, the introduction of a new vaccine, especially one relying on self-pay, should examine whether the public is willing to purchase the novel vaccine. Most studies of willingness to pay for vaccines have focused on endemic diseases in both developing and developed countries. Studies gauging willingness to pay for vaccines targeting diseases such as dengue,15,17-19 pneumococcal pneumonia,20,21 seasonal influenza,20,22,23 and human papillomavirus (HPV)24-26 have found a range of variables to be associated with willingness to pay, including demographic, socioeconomic, attitude, and vaccine attribute factors. Additionally, a systematic review found that willingness to pay for vaccines varies depending on vaccine type and disease severity, with consumers willing to pay more for vaccines against diseases with high morbidity and mortality.27 Several studies have examined willingness to pay for an Ebola vaccine among high priority populations (e.g., health care workers) and general populations of Ebola-affected countries in West Africa; however, findings may not be relevant to the U.S. domestic context.28-30

The purpose of this study was to assess willingness to pay for an Ebola vaccine among a U.S. national sample during the height of the 2014–2016 Ebola epidemic in West Africa. Findings may help shed light on the trade-off that Americans are willing to make regarding personal wealth versus perceived risk of death or disease during a highly publicized infectious disease epidemic occurring elsewhere in the world.

Results

A total of 1471 participants completed the survey. Of those, 30 persons did not answer the question about willingness to pay for an Ebola vaccine. Only participants who answered the question regarding willingness to pay for an Ebola vaccine (n = 1,447) were included in analyses. Among participants (N = 1,447), 583 (40.3%) would not pay out of pocket for an Ebola vaccine; 864 (59.7%) would pay at least $1. Among those willing to pay at least $1: 570 (66.0%) would pay $1–50; 174 (20.1%) would pay $51–100; and 120 (13.9%) would pay more than $100.

In bivariate analyses, the proportion of participants willing to pay at least $1 for an Ebola vaccine was higher among those with higher levels of education, higher levels of income, history of international travel in the past 12 months, and interest in getting an Ebola vaccine (Table 1). Participants who were willing to pay at least $1 for an Ebola vaccine had higher mean scores on scales measuring Ebola-related knowledge, Ebola-driven behaviors (information seeking and hand hygiene), perceived susceptibility to Ebola, perceived severity of Ebola, support for U.S. government spending to control Ebola, support for U.S. government intervention to control Ebola internationally, and support for U.S. government leadership in confronting emerging epidemics worldwide.

Table 1.

Characteristics of Ebola survey participants – United States, 2015 (N = 1447).

Characteristics Total sample (n = 1447)
No. (%)* or Mean (SD)
Not willing to pay at least $1
(n = 583)
No. (%)* or Mean (SD)
Willing to pay at least $1 (864)
No. (%)* or Mean (SD)
Chi square or t-test
p-value
Demographics        
Age 49.9 (17.1) 50.95 (16.9) 49.2 (17.3) .062
Sex       .138
  Male 733 (50.7) 306 (52.5) 427 (49.4)  
  Female 714 (49.3) 277 (47.5) 437 (50.6)  
Race       .404
  White 1064 (73.5) 440 (75.5) 624 (72.2)  
  Black 116 (8.0) 41 (7.0) 75 (8.7)  
  Hispanic 140 (9.7) 50 (8.6) 90 (10.4)  
  Other 127 (8.8) 52 (8.9) 75 (8.7)  
Education       .002
  Less than high school 123 (8.5) 51 (8.7) 72 (8.3)  
  High school 396 (27.4) 185 (31.7) 211 (24.4)  
  Some college 420 (29.0) 174 (29.8) 246 (28.5)  
  Bachelor's degree or higher 508 (35.1) 173 (29.7) 335 (38.8)  
Annual household income       .036
  $0–49,999 561 (38.8) 249 (42.7) 312 (36.1)  
  $50,000–99,999 465 (32.1) 179 (30.7) 286 (33.1)  
  $100,000 or more 421 (29.1) 155 (26.6) 266 (30.8)  
Region       .436
  Northeast 262 (18.1) 117 (20.1 145 (16.8)  
  Midwest 331 (22.9) 130 (22.3) 201 (23.3)  
  South 526 (36.4) 210 (36.0) 316 (36.6)  
  West 328 (22.7) 126 (21.6) 202 (23.4)  
International travel in the past 12 months       <.001
  No 1252 (86.5) 532 (91.3) 720 (83.4)  
  Yes 194 (13.4) 51 (8.7) 143 (16.6)  
 Interested in getting an Ebola vaccine       <.001
  No 945 (65.3) 510 (87.9) 435 (50.4)  
  Yes 498 (34.4) 70 (12.1) 428 (49.6)  
 Ebola-related knowledge 4.5 (2.2) 4.3 (2.3) 4.6 (2.1) .012
Ebola-driven behaviors        
  Information seeking 5.5 (1.6) 5.3 (1.5) 5.6 (1.6) .002
  Hand hygiene 5.4 (2.0) 5.2 (1.9) 5.5 (2.1) .004
Personal beliefs        
  Perceived susceptibility to Ebola 7.8 (3.2) 7.5 (3.2) 8.1 (3.2) .003
  Perceived severity of Ebola 19.0 (3.2) 18.7 (3.3) 19.2 (3.2) .008
  Personal fear of Ebola 12.4 (3.3) 12.4 (3.3) 12.4 (3.3) .721
National beliefs        
  Support USG spending money to control Ebola 11.2 (2.3) 10.6 (2.4) 11.6 (2.2) <.001
  Support USG intervention to curb the Ebola epidemic internationally 13.5 (3.2) 12.7 (3.4) 14.0 (3.0) <.001
  National fear / isolationism 19.2 (4.9) 19.2 (5.0) 19.1 (4.8) .645
  Support USG leadership in
Confronting emerging epidemics
9.2 (2.4) 8.7 (2.5) 9.6 (2.3) <.001
*

Percentages for some variables may not add to 100 due to missing data.

In weighted multivariable analyses, willingness to pay at least $1 for an Ebola vaccine was associated with international travel in the past 12 months (aOR = 2.12; 95% CI = 1.46, 3.09; p<.001), interest in getting an Ebola vaccine (aOR = 6.72; 95% CI = 5.02, 8.99; p<.001), beliefs that the U.S. government should spend money to control Ebola (aOR = 1.12; 95% CI = 1.06, 1.19; p<.001), and beliefs that the U.S. government should assume worldwide leadership in confronting emerging epidemics (aOR = 1.09; 95% CI = 1.03, 1.16; p = .003) (Table 2).

Table 2.

Final multivariable models of factors associated with willingness to pay for an Ebola virus vaccine, determined using stepwise logistic regression with forward selection, among a U.S. National Sample – United States, 2015.

Variable Adjusted model OR (95% CI) p-value
Among the full sample:    
Willingness to pay at least $1    
 International travel in the past 12 months 2.12 (1.46, 3.09) <.001
 Interest in an Ebola vaccine 6.72 (5.02, 8.99) <.001
 Support USG spending money to control Ebola 1.12 (1.06, 1.19) <.001
 Support USG leadership in confronting emerging epidemics 1.09 (1.03, 1.16) .003
Willingness to pay at least $50    
 International travel in the past 12 months 3.46 (2.43, 4.92) <.001
 Interest in an Ebola vaccine 3.63 (2.73, 4.83) <.001
 Support USG spending money to control Ebola 1.09 (1.02, 1.18) .016
 Support USG leadership in confronting emerging epidemics 1.09 (1.02, 1.17) .010
Willingness to pay at least $100    
 International travel in the past 12 months 3.07 (1.95, 4.84) <.001
 Interest in an Ebola vaccine 3.36 (2.23, 5.05) <.001
 Information seeking about Ebola 1.18 (1.04, 1.35) .010
 Support USG leadership in confronting emerging epidemics 1.13 (1.03, 1.23) .007
Among participants willing to pay at least $1:    
Willingness to pay at least $100    
Region    
  Northeast Ref
  Midwest 0.50 (0.26, 0.93) .028
  South 0.50 (0.28, 0.85) .011
  West 0.71 (0.41, 1.26) .245
International travel in the past 12 months 2.39 (1.50, 3.81) <.001
Interest in an Ebola vaccine 1.66 (1.10, 2.51) .017
Information seeking about Ebola 1.22 (1.08, 1.39) .002

Willingness to pay more than $50 for an Ebola vaccine was associated with similar variables: international travel in the past 12 months (aOR = 3.46; 95% CI = 2.43, 4.92; p<.001), interest in getting an Ebola vaccine (aOR = 3.63; 95% CI = 2.73, 4.83; p<.001), beliefs that the U.S. government should spend money to control Ebola (aOR = 1.09; 95% CI = 1.02, 1.18; p = .016), and beliefs that the U.S. government should assume worldwide leadership in confronting emerging epidemics (aOR = 1.09; 95% CI = 1.02, 1.17; p = .010).

Among the full sample, willingness to pay more than $100 was associated with international travel in the past 12 months (aOR = 3.07; 95% CI = 1.95, 4.84; p<.001), interest in getting an Ebola vaccine (aOR = 3.63; 95% CI = 2.23, 5.05; p<.001), information seeking about Ebola (aOR = 1.18; 95% CI = 1.04, 1.35; p<.010), and beliefs that the U.S. government should assume worldwide leadership in confronting emerging epidemics (aOR = 1.13; 95% CI = 1.03, 1.23; p = .007). Among participants who would pay at least $1 for an Ebola vaccine, willingness to pay more than $100 was associated with international travel in the past 12 months (aOR = 2.39; 95% CI = 1.50, 3.81; p<.001), interest in getting an Ebola vaccine (aOR = 1.66; 95% CI = 1.10, 2.51; p<.017), and information seeking about Ebola (aOR = 1.22; 95% CI = 1.08, 1.39; p = .002). Compared to participants who lived in the Northeast, participants who lived in the Midwest (aOR = 0.50; 95% CI = 0.26, 0.93; p = .028) or South (aOR = 0.50; 95% CI = 0.28, 0.85; p = .011), were less likely to be willing to pay more than $100.

Discussion

This study provides novel information regarding willingness to pay for an Ebola vaccine among a U.S. national sample during the 2014–2016 epidemic in West Africa. While previous studies have assessed willingness to pay for an Ebola vaccine in West Africa,28-30 findings from these studies are not generalizable to the U.S. population. In the present study, approximately 60% of participants were willing to pay at least $1 for an Ebola vaccine, despite minimal risk of an outbreak in the United States. Willingness to pay is an indicator of the perceived value placed on an Ebola vaccine,14 suggesting U.S citizens would value an Ebola vaccine during an epidemic — even if the epidemic primarily affected countries in an international setting. This finding has potential implications for Ebola vaccine financing, particularly for self-pay. Vaccine availability in the U.S. could potentially offset costs in areas such as West Africa, where the need is great, but the ability to pay is limited.31

Findings indicated two variables, international travel in the past 12 months and interest in an Ebola vaccine, were associated with willingness to pay across all price points. Participants with a history of international travel might be more willing to pay for an Ebola vaccine, even in excess of $100, because they are concerned about travel-related infectious disease risks. International travel is a common risk factor for infectious disease acquisition and importation to the United States.32 Once an Ebola vaccine is licensed, vaccinating international travelers against Ebola, particularly those working in health-related settings,33 might be an effective strategy to ensure the safety of U.S. travelers and reduce the risk of the Ebola introduction nationally.

The finding that interest in an Ebola vaccine was associated with willingness to pay out of pocked for an Ebola vaccine was expected. If an individual feels at risk for Ebola, then they would value being protected against Ebola; and logically be willing to pay money for a vaccine. Of note, participants’ interest in getting an Ebola vaccine was not synonymous with being willing to pay for a vaccine. In fact, over 400 participants did not express interest in getting an Ebola vaccine, yet would be willing to pay at least $1 for a vaccine. There are several potential explanations for this result. First, this finding could reflect a realistic assessment of Ebola risk. Participants who were not interested in getting an Ebola vaccine might have accurately assessed that they were not likely to get Ebola in the United States, and therefore not interested in getting a vaccine; however, they would be willing to pay a nominal amount (e.g., $1) for an Ebola vaccine if offered. Second, this finding might reflect consistency with a study of acceptability and willingness to pay for an Ebola vaccine in Nigeria.28 In that study, many participants would only accept an Ebola vaccine after observing other people receive the vaccine first. Similarly, participants in the present study might not have been interested in getting an Ebola vaccine unless they could be sure that it was safe and effective, as safety is a common reason for not be willing to get a vaccine.34 Yet, if they were to get a vaccine, they would be willing to pay out of pocket for it. Third, this finding could reflect the hypothetical nature of the questions being asked. There could have been unmeasured factors, including vaccine characteristics (e.g., safety, efficacy, side-effects)15,17,24 and timeliness of vaccine availability,35 which might have impacted participants’ answers regarding vaccine interest and willingness to pay.

Another important finding is that national threat beliefs, including beliefs that the U.S. government should spend money to control Ebola and beliefs that the U.S. government should assume worldwide leadership in confronting emerging epidemics, were significantly associated with willingness to pay for an Ebola vaccine at multiple price points. This finding is consistent with previous research reporting an association between national threat beliefs and interest in an Ebola vaccine,33 indicating that people who consider Ebola a national priority might consider it a personal priority, as well. This finding might also reflect an appreciation of the fact that multiple levels of action are necessary to protect individuals against emerging infectious diseases, including interventions at the individual level (e.g., vaccination), the national level (e.g., enhancing surveillance and preventing disease importation), and the international level (e.g., developing collaborations to stem emerging infectious disease epidemics at their source).36

Limitations

This study has several limitations. First, questions about the Ebola vaccine were hypothetical; thus, it is unknown if findings would apply to an actual vaccine. Willingness to pay for an actual vaccine would likely depend on cost, as well as other vaccine-related factors. Second, this study did not account for vaccine characteristics (e.g., safety and efficacy) which have been demonstrated to impact willingness to pay for other vaccines.15,17,24 Third, this study was conducted during the height of the Ebola epidemic in West Africa, and “Fearbola”13 epidemic in the United States. It is unclear if findings would be similar under non-outbreak circumstances. Fourth, this study relied on self-report; thus social desirability bias might have influenced participant responses. Finally, the survey did not collect data regarding participants’ knowledge or attitudes regarding costs of a typical vaccine, such as the seasonal influenza vaccine. Thus, it is unclear how participants’ willingness to pay for an Ebola vaccine compares to willingness to pay for other vaccines.

Conclusion

To our knowledge, this study is the first to assess willingness to pay for an Ebola vaccine in the United States. This study provides valuable information about characteristics of individuals willing to pay for an Ebola vaccine during the height of the 2014–2016 Ebola epidemic, a highly publicized epidemic in an international setting. Findings indicated that international travel and interest in an Ebola vaccine were the most salient predictors of willingness to pay across all price points, and might be relevant in the event of future emerging infectious disease threats. Once an Ebola vaccine is licensed, further assessment of willingness to pay will be critical. Future studies should examine willingness to pay for vaccines against emerging infectious diseases both in the United States and abroad.

Materials and methods

The survey methodology for this study has been previously described.33 Briefly, a nationally representative survey of U.S. adults was conducted from April 30–May 8, 2015, using the GfK Group's KnowlegePanel®. The KnowlegePanel® survey employed a probability-based web panel using an address-based sampling methodology, which covers households regardless of their phone status. This allowed for a diverse and representative household-based sample, including hard-to-reach individuals, with oversampling from census block groups within high-density minority communities. Data weights were employed so that the sample distribution matched that of the U.S. adult population. The target population consisted of non-institutionalized, English-language survey-taking adults, age 18 and over, residing in the United States. This study was approved by the IRB at the researchers’ institution.

Measures

The main outcome measures were willingness to pay at least $1; more than $50; and more than $100 for an Ebola vaccine. Participants were asked, “How much would you pay out of pocket for an Ebola vaccine if your health insurance did not cover the cost of the vaccine?” Answer choices included: $0 (I would not pay for an Ebola vaccine); $1–$50; $51–$100; $101–$150; $151–$200; more than $200. Due to small numbers of respondents, the last three response options were combined into one category: more than $100.

Predictor variables included background factors (age, sex, race, education, income, region, and history of international travel in the past 12 months); interest in getting an Ebola vaccine (indicated by responding “very likely” or “fairly likely” when asked “How likely would you be to get a vaccine that would prevent you from getting Ebola?”); Ebola-related knowledge; Ebola-related behaviors (information seeking and hand hygiene); and Ebola-related attitudes (personal and national threat beliefs). Psychometric properties of Ebola-related knowledge, behavior, and attitude scales among participants who answered the question regarding willingness to pay for an Ebola vaccine are presented in Table 3.

Table 3.

Items and measurement characteristics for scale variables among a U.S. National Sample (N = 1,447) — United States, 2015.

Construct Items   Number of items Range Cronbach's Alpha
Knowledge Ebola is a contagious disease (True)   8 0–8 .753
  A person infected with Ebola is not contagious until after the symptoms appear (True)        
  Ebola can be spread through direct contact with bodily fluids (e.g. urine, sweat, saliva) of an infected individual (True)        
  Ebola can be spread through sexual contact (True)        
  Currently, there is no FDA approved drug for treating individuals who are infected with the Ebola virus (True)        
  The Ebola virus can live on surfaces outside of the body for up to 6 days (True)        
  There is no vaccine currently available to prevent infection with Ebola (True)        
  If a person is infected with Ebola, symptoms may appear from 2 to 21 days after they are exposed to the virus (True)        
Ebola-driven behaviors          
 Information I search for new information related to the Ebola outbreak   2 2–10 .647
 seeking I follow the news stories related to the Ebola outbreak        
 Hand hygiene Because of the Ebola virus, I am more likely to use hand sanitizers   2 2–10 .943
  Because of the Ebola virus, I wash my hands with soap more frequently        
Personal threat beliefs          
 Perceived My risk of getting infected with Ebola is high   4 4–20 .840
 susceptibility I am concerned about getting infected with Ebola        
  There is a good possibility that I will get infected with Ebola        
  Ebola poses a threat to me personally        
 Perceived Ebola is a severe disease   5 5–25 .788
 severity If a person becomes infected with Ebola, it is likely that they will die        
  If a person becomes infected with Ebola, it is likely that they would have a hard time recovering        
  Ebola is more deadly than HIV/AIDS        
  Ebola is more deadly than the measles        
 Personal fear I would not want to be in the same classroom or work space with a person who had previously been diagnosed with Ebola   4 4–20 .762
  If I sit next to someone on the airplane from countries where Ebola has been detected, there is a strong likelihood that I would get infected with Ebola        
  I would not travel to Africa because of the Ebola epidemic        
  I would not sit next to someone who is coughing because likelihood that I would get infected with Ebola        
National threat beliefs          
 USG spending to control Ebola It is important to support the US government spending money to fight Ebola in African countries   3 3–15 .874
  It is important to support the US spending money to conduct Ebola research to develop treatments for people who are infected with Ebola        
  It is important to support the US spending money to conduct Ebola research to develop a vaccine to protect against infection from Ebola        
 USG intervention support scale I support the US policy to allocate billions of dollars to assist countries in confronting the Ebola crisis   4 4–20 .841
  I support the US policy to send troops to Africa to fight the Ebola epidemic        
  I support the US sending medical teams to countries affected by Ebola        
  I support the US sending humanitarian aid in the form of food and health supplies to countries affected by Ebola        
 National fear / isolationism Ebola poses a threat to the national security of the United States   6 6–30 .861
  People coming from countries where Ebola has been detected should be quarantined until tested for the virus        
  The only way to stop Ebola spreading in the United States is to halt flights from going to and out of countries where cases of Ebola have been detected        
  Bringing Ebola patients back to the US for treatment puts Americans at risk for infection        
  Bringing Ebola patients back to the US for treatment may create a widespread Ebola infection in the US        
  Students from African countries where Ebola has been detected should not be permitted to enroll in colleges or universities in the United States        
 USG leadership scale If new or emerging epidemics threaten countries, the U.S. should assume the worldwide leadership in confronting this health threat by sending economic aid   3 3–15 .806
  If new or emerging epidemics threaten countries, the U.S. should assume the worldwide leadership in confronting this health threat by sending health care and medicine        
  If new or emerging epidemics threaten countries, the U.S. should assume the worldwide leadership in confronting this health threat by sending military troops        

Analyses were conducted with SPSS (version 24). Cronbach alphas were calculated for scale variables to measure internal consistency, as an indicator of reliability. Chi-square tests (for dichotomous and categorical variables) and t-tests (for continuous variables) were conducted to assess differences in characteristics among participants willing to pay at least $1 for an Ebola vaccine compared to participants not willing to pay at least $1 for an Ebola vaccine. Unadjusted logistic regressions were conducted to assess the association between predictor and outcome variables. All variables significant at the p = .10 level in unadjusted regression analyses were included as potential independent variables in weighted multivariable analyses. Stepwise logistic regression with forward selection was used to determine the best combination of variables associated with willingness to pay for an Ebola vaccine using the most parsimonious model. Willingness to pay more than $100 was assessed among the full sample and among participants willing to pay at least $1.

Disclosure of potential conflicts of interest

No potential conflicts of interest were disclosed.

Acknowledgments

The authors wish to thank Chris Martin, from the Department of Sociology, Emory University, and Nahiri Patel, from the Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, for their tremendous assistance with this study.

References

  • 1.Bell BP, Damon IK, Jernigan DB, Kenyon TA, Nichol ST, O'Connor JP, Tappero JW. Overview, Control Strategies, and Lessons Learned in the CDC Response to the 2014–2016 Ebola Epidemic. MMWR Suppl. 2016;65(3):4–11. doi: 10.15585/mmwr.su6503a2. PMID:27389903. [DOI] [PubMed] [Google Scholar]
  • 2.World Health Organization Statement on the 1st meeting of the IHR Emergency Committee on the 2014 Ebola outbreak in West Africa. http://www.who.int/mediacentre/news/statements/2014/ebola-20140808/en/ Accessed December 4, 2017.
  • 3.De Santis O, Audran R, Pothin E, Warpelin-Decrausaz L, Vallotton L, Wuerzner G, Cochet C, Estoppey D, Steiner-Monard V, Lonchampt S, et al.. Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study. Lancet Infect Dis. 2016;16(3):311–320. doi: 10.1016/S1473-3099(15)00486-7. PMID:26725450. [DOI] [PubMed] [Google Scholar]
  • 4.Widdowson MA, Schrag SJ, Carter RJ, Carr W, Legardy-Williams J, Gibson L, Lisk DR, Jalloh MI, Bash-Taqi DA, Kargbo SA, et al.. Implementing an Ebola Vaccine Study – Sierra Leone. MMWR Suppl. 2016;65(3):98–106. doi: 10.15585/mmwr.su6503a14. PMID:27387395. [DOI] [PubMed] [Google Scholar]
  • 5.Zhu FC, Wurie AH, Hou LH, Liang Q, Li YH, Russell JB, Wu SP, Li JX, Hu YM, Guo Q, et al.. Safety and immunogenicity of a recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in Sierra Leone: a single-centre, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet. 2017;389(10069):621–628. doi: 10.1016/S0140-6736(16)32617-4. PMID:28017399. [DOI] [PubMed] [Google Scholar]
  • 6.Milligan ID, Gibani MM, Sewell R, Clutterbuck EA, Campbell D, Plested E, Nuthall E, Voysey M, Silva-Reyes L, McElrath MJ, et al.. Safety and Immunogenicity of Novel Adenovirus Type 26- and Modified Vaccinia Ankara-Vectored Ebola Vaccines: A Randomized Clinical Trial. JAMA. 2016;315(15):1610–1623. doi: 10.1001/jama.2016.4218. PMID:27092831. [DOI] [PubMed] [Google Scholar]
  • 7.Henao-Restrepo AM, Camacho A, Longini IM, Watson CH, Edmunds WJ, Egger M, Carroll MW, Dean NE, Diatta I, Doumbia M, et al.. Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ca Suffit!). Lancet. 2017;389(10068):505–518. doi: 10.1016/S0140-6736(16)32621-6. PMID:28017403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Venkatraman N, Silman D, Folegatti PM, Hill AVS. Vaccines against Ebola virus. Vaccine. 2017. [Epub ahead of print]. doi: 10.1016/j.vaccine.2017.07.054. [DOI] [PubMed] [Google Scholar]
  • 9.Gsell PS, Camacho A, Kucharski AJ, Watson CH, Bagayoko A, Nadlaou SD, Dean NE, Diallo A, Diallo A, Honora DA, et al.. Ring vaccination with rVSV-ZEBOV under expanded access in response to an outbreak of Ebola virus disease in Guinea, 2016: an operational and vaccine safety report. Lancet Infect Dis. 2017;17(12):1276–1284. doi: 10.1016/S1473-3099(17)30541-8. PMID:29033032. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 10.Chevalier MS, Chung W, Smith J, Weil LM, Hughes SM, Joyner SN, Hall E, Srinath D, Ritch J, Thathiah P, et al.. Ebola virus disease cluster in the United States–Dallas County, Texas, 2014. MMWR Morb Mortal Wkly Rep. 2014;63(46):1087–1088. PMID:25412069. [PMC free article] [PubMed] [Google Scholar]
  • 11.Yacisin K, Balter S, Fine A, Weiss D, Ackelsberg J, Prezant D, Wilson R, Starr D, Rakeman J, Raphael M, et al.. Ebola virus disease in a humanitarian aid worker – New York City, October 2014. MMWR Morb Mortal Wkly Rep. 2015;64(12):321–323. PMID:25837242. [PMC free article] [PubMed] [Google Scholar]
  • 12.Towers S, Afzal S, Bernal G, Bliss N, Brown S, Espinoza B, Jackson J, Judson-Garcia J, Khan M, Lin M, et al.. Mass Media and the Contagion of Fear: The Case of Ebola in America. PLoS One. 2015;10(6):e0129179. doi: 10.1371/journal.pone.0129179. PMID:26067433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.James JJ, Fearbola. Disaster Med Public Health Prep. 2014;8(6):465–466. doi: 10.1017/dmp.2014.155. PMID:25859687. [DOI] [PubMed] [Google Scholar]
  • 14.Laxminarayan R, Jamison DT, Krupnick AJ, Norheim OF. Valuing vaccines using value of statistical life measures. Vaccine. 2014;32(39):5065–5070. doi: 10.1016/j.vaccine.2014.07.003. PMID:25045822. [DOI] [PubMed] [Google Scholar]
  • 15.Harapan H, Fajar JK, Sasmono RT, Kuch U. Dengue vaccine acceptance and willingness to pay. Hum Vaccin Immunother. 2017;13(4):786–790. doi: 10.1080/21645515.2016.1259045. PMID:27905832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Seib K, Pollard AJ, de Wals P, Andrews RM, Zhou F, Hatchett RJ, Pickering LK, Orenstein WA. Policy making for vaccine use as a driver of vaccine innovation and development in the developed world. Vaccine. 2017;35(10):1380–1389. doi: 10.1016/j.vaccine.2016.10.080. PMID:28253995. [DOI] [PubMed] [Google Scholar]
  • 17.Hadisoemarto PF, Castro MC. Public acceptance and willingness-to-pay for a future dengue vaccine: a community-based survey in Bandung, Indonesia. PLoS Negl Trop Dis. 2013;7(9):e2427. doi: 10.1371/journal.pntd.0002427. PMID:24069482. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Lee JS, Mogasale V, Lim JK, Carabali M, Sirivichayakul C, Anh DD, Lee KS, Thiem VD, Limkittikul K, Tho le H, et al.. A Multi-country Study of the Household Willingness-to-Pay for Dengue Vaccines: Household Surveys in Vietnam, Thailand, and Colombia. PLoS Negl Trop Dis. 2015;9(6):e0003810. doi: 10.1371/journal.pntd.0003810. PMID:26030922. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19.Godoi IP, Santos AS, Reis EA, Lemos LL, Brandão CM, Alvares J, Acurcio FA, Godman B, Guerra Júnior AA. Consumer Willingness to Pay for Dengue Vaccine (CYD-TDV, Dengvaxia(R)) in Brazil; Implications for Future Pricing Considerations. Front Pharmacol. 2017;8:41. doi: 10.3389/fphar.2017.00041. PMID:28210223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Hou Z, Jie C, Yue D, Fang H, Meng Q, Zhang Y. Determinants of willingness to pay for self-paid vaccines in China. Vaccine. 2014;32(35):4471–4477. doi: 10.1016/j.vaccine.2014.06.047. PMID:24968160. [DOI] [PubMed] [Google Scholar]
  • 21.Prosser LA, Ray GT, O'Brien M, Kleinman K, Santoli J, Lieu TA. Preferences and willingness to pay for health states prevented by pneumococcal conjugate vaccine. Pediatrics. 2004;113(2):283–290. doi: 10.1542/peds.113.2.283. PMID:14754939. [DOI] [PubMed] [Google Scholar]
  • 22.Johnston SS, Rousculp MD, Palmer LA, Chu BC, Mahadevia PJ, Nichol KL. Employees' willingness to pay to prevent influenza. Am J Manag Care. 2010;16(8):e205–214. PMID:20690787. [PubMed] [Google Scholar]
  • 23.Shono A, Kondo M. Parents' preferences for seasonal influenza vaccine for their children in Japan. Vaccine. 2014;32(39):5071–5076. doi: 10.1016/j.vaccine.2014.07.002. PMID:25063570. [DOI] [PubMed] [Google Scholar]
  • 24.Brown DS, Johnson FR, Poulos C, Messonnier ML. Mothers' preferences and willingness to pay for vaccinating daughters against human papillomavirus. Vaccine. 2010;28(7):1702–1708. doi: 10.1016/j.vaccine.2009.12.024. PMID:20044060. [DOI] [PubMed] [Google Scholar]
  • 25.Kruiroongroj S, Chaikledkaew U, Thavorncharoensap M. Knowledge, acceptance, and willingness to pay for human papilloma virus (HPV) vaccination among female parents in Thailand. Asian Pac J Cancer Prev. 2014;15(13):5469–5474. doi: 10.7314/APJCP.2014.15.13.5469. PMID:25041020. [DOI] [PubMed] [Google Scholar]
  • 26.Alder S, Gustafsson S, Perinetti C, Mints M, Sundstrom K, Andersson S. Mothers' acceptance of human papillomavirus (HPV) vaccination for daughters in a country with a high prevalence of HPV. Oncol Rep. 2015;33(5):2521–2528. doi: 10.3892/or.2015.3817. PMID:25738832. [DOI] [PubMed] [Google Scholar]
  • 27.Kim SY, Sagiraju HK, Russell LB, Sinha A. Willingness-To-Pay for Vaccines in Low- and Middle-Income Countries: A Systematic Review. Annals of Vaccines and Immunization. 2014;1(1):1001. [Google Scholar]
  • 28.Ughasoro MD, Esangbedo DO, Tagbo BN, Mejeha IC. Acceptability and Willingness-to-Pay for a Hypothetical Ebola Virus Vaccine in Nigeria. PLoS Negl Trop Dis. 2015;9(6):e0003838. doi: 10.1371/journal.pntd.0003838. PMID:26076007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29.Huo X, Shi G, Li X, Lai X, Deng L, Xu F, Chen M, Wei Q, Samba T, Liang X. Knowledge and attitudes about Ebola vaccine among the general population in Sierra Leone. Vaccine. 2016;34(15):1767–72. PMID:26928073. [DOI] [PubMed] [Google Scholar]
  • 30.Esangbedo DO, Ughasoro MD, Tagbo BN, Olowu A, Anikene C, Iwegbulam CC. Health-Care Workers' Perspectives on Ebola Virus Vaccine: A Focus Group and In-Depth Interview Interventional Study. Am J Trop Med Hyg. 2016;95(3):654–62. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 31.Lang J, Wood SC. Development of orphan vaccines: an industry perspective. Emerg Infect Dis. 1999;5(6):749–56. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 32.Lammert SM, Rao SR, Jentes ES, Fairley JK, Erskine S, Walker AT, Hagmann SH, Sotir MJ, Ryan ET, LaRocque RC. Refusal of recommended travel-related vaccines among U.S. international travellers in Global TravEpiNet. J Travel Med. 2016;24(1). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 33.Painter JE, DiClemente RJ, von Fricken ME. Interest in an Ebola vaccine among a U.S. national sample during the height of the 2014–2016 Ebola outbreak in West Africa. Vaccine. 2017;35(4):508–512. [DOI] [PubMed] [Google Scholar]
  • 34.MacDonald NE, SAGE Working Group on Vaccine Hesitancy. Vaccine hesitancy: Definition, scope and determinants. Vaccine. 2015;33(34):4161–4. PMID:25896383. [DOI] [PubMed] [Google Scholar]
  • 35.Borse RH, Shrestha SS, Fiore AE, Atkins CY, Singleton JA, Furlow C, Meltzer MI. Effects of vaccine program against pandemic influenza A (H1N1) virus, United States, 2009–2010. Emerg Infect Dis. 2013;19:439–48. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 36.U.S. Centers for Disease Control and Prevention A CDC Framework for Preventing Infectious Diseases: Sustaining the Essentials and Innovating for the Future. 2011. https://www.cdc.gov/oid/docs/id-framework.pdf Accessed December 4, 2017.

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